Submitted on April 5, 2004
Revised on April 21, 2004
Accepted on April 5, 2004
An interpreted history of the cholesterol controversy
Daniel Steinberg
Medicine Dept., University of California San Diego, La Jolla, CA 92093-0682
Corresponding Author: dsteinberg{at}ucsd.edu
This is the first of a series of reviews of the controversy that swirled around the “lipid hypothesis” of atherosclerosis for so many years. Today, in the era of the statins, there is no longer any doubt about the value of lowering blood cholesterol levels. In fact, ‘the lower the better’ is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is worth telling for its own sake and because remembering it may help us avoid similar mistakes in the future.
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