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A more recent version of this article appeared on January 1, 2005

Papers In Press, published online ahead of print November 16, 2004
J. Lipid Res., doi:10.1194/jlr.R400011-JLR200
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Submitted on October 13, 2004
Revised on November 10, 2004
Accepted on November 10, 2004

Thematic review series: recent insights into the biology of macrophage scavenger receptors

Siamon Gordon and David R. Greaves

Dunn School of Pathology, University of Oxford, Oxford OX1 3RE

Corresponding Author: david.greaves{at}path.ox.ac.uk

Scavenger receptors were originally defined by their ability to bind and internalize modified lipoproteins. Macrophages express at least six structurally different cell surface receptors for modified forms of LDL that contribute to foam cell formation in atherosclerosis. In addition to their role in the pathology of atherosclerosis macrophage scavenger receptors, especially SR-A, play critical roles in innate immunity, apoptotic cell clearance and tissue homeostasis. In this review we highlight recent advances in understanding the biology of macrophage scavenger receptors as pattern recognition receptors for both infectious non-self (pathogens) and modified self (apoptotic cells and modified LDL). We critically evaluate the potential of scavenger receptors and their ligands as targets for therapeutic intervention in human disease.


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