Advertisement
J. Lipid Res.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on February 1, 2006 Originally published In Press as doi:10.1194/jlr.R500016-JLR200 on December 12, 2005

Papers In Press, published online ahead of print December 7, 2005
J. Lipid Res., doi:10.1194/jlr.R500016-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
R500016-JLR200v1
R500016-JLR200v2
47/2/233    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Eastman, R. T.
Right arrow Articles by Van Voorhis, W. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eastman, R. T.
Right arrow Articles by Van Voorhis, W. C.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Submitted on November 1, 2005
Revised on December 6, 2005
Accepted on December 6, 2005

Fighting parasitic disease by blocking protein farnesylation

Richard T. Eastman, Frederick S. Buckner, Kohei Yokoyama, Michael H. Gelb, and Wesley C. Van Voorhis

University of Washington, Seattle, WA 98195-7185

Corresponding Author: richeast{at}u.washington.edu

Protein prenylation is a form of post-translational modification that occurs in most, if not all, eukaryotic cells. Protein farnesyltransferase inhibitors (PFTIs) have been developed as anti-cancer chemotherapeutics. Recent studies have investigated the use of protein prenylation inhibitors for the treatment of eukaryotic pathogens. To accelerate progress in the development of therapeutics for protozoan parasitic diseases, researchers are applying the knowledge gained from developing PFTIs for cancer treatment to the potential use as anti-parasitic agents. Inhibitors of protein farnesyltransferase have already been shown to be efficacious in the treatment of eukaryotic pathogens in animal models, including Trypanosoma brucei and Plasmodium falciparum. Here, we summarize the current evidence and progress that supports targeting prenylation enzymes for the treatment of parasitic diseases.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Eukaryot CellHome page
D. Z. Mokry, S. P. Manandhar, K. A. Chicola, G. M. Santangelo, and W. K. Schmidt
Heterologous Expression Studies of Saccharomyces cerevisiae Reveal Two Distinct Trypanosomatid CaaX Protease Activities and Identify Their Potential Targets
Eukaryot. Cell, December 1, 2009; 8(12): 1891 - 1900.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
K. A. Grabinska, P. Magnelli, and P. W. Robbins
Prenylation of Saccharomyces cerevisiae Chs4p Affects Chitin Synthase III Activity and Chitin Chain Length
Eukaryot. Cell, February 1, 2007; 6(2): 328 - 336.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
K. T. Lane and L. S. Beese
Thematic review series: Lipid Posttranslational Modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I
J. Lipid Res., April 1, 2006; 47(4): 681 - 699.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2005 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement