Submitted on March 31, 2006
Revised on May 4, 2006
Accepted on May 8, 2006
What have we learned about HDL metabolism from kinetic studies in humans?
Shirya Rashid, Bruce W. Patterson, and Gary F. Lewis
Medicine, Endocrinology, Toronto General Hospital, Toronto, ON M5G 2C4
Corresponding Author: gary.lewis{at}uhn.on.ca
Plasma measurements of lipids, lipoproteins and apolipoproteins provide information on the static levels of these fractions without providing key information on the dynamic fluxes of lipoproteins in the circulation. Kinetic studies, in contrast, provide additional information on the production and clearance rates of lipoproteins and the flow of lipids and apolipoproteins through lipoprotein fractions. This information is crucial in accurately delineating the metabolism of HDL in plasma, since plasma concentrations of HDL are the net result of de novo production and catabolism of HDL, as well as the recycling of HDL particles and contribution to HDL from components of other lipoproteins. Studies aimed at measuring the metabolism of HDL particles have shown that HDL metabolism in vivo is complex and consists of multiple components. Kinetic studies provide a window into the metabolism of HDL, allowing us to better understand mechanisms of HDL lowering in human conditions and the functionality of HDL particles. Here we review the progress in our understanding of HDL metabolism derived from in vivo kinetic studies - focusing primarily on studies in humans, but also reviewing key studies in animal models.
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