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J. Lipid Res.
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A more recent version of this article appeared on April 1, 2009

Papers In Press, published online ahead of print November 20, 2008
J. Lipid Res., doi:10.1194/jlr.R800081-JLR200
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Submitted on November 10, 2008
Accepted on November 19, 2008

New technologies for delineating and characterising the lipid exome: prospects for understanding familial combined hyperlipidemia

Stuart D. Horswell, Helen E. Ringham, and Carol C. Shoulders

Genomic & Molecular Medicine, MRC Clinical Sciences Centre, London W12 0NN

Corresponding Author: carol.shoulders{at}csc.mrc.ac.uk

This review summarises the progress made in cutting through the biological and genetic complexity of the Gordian-knot that is Familial Combined Hyperlipidemia. We particularly focus on how the application of new genomic technologies, especially massively parallel sequencing and high-throughput genotyping platforms, promise to accelerate the gene discovery process in this common, highly atherogenic disorder, with important diagnostic and therapeutic implications.


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Related Webpages:

JLR 50th Anniversary Collections
Anniversary Collection::Atherogenesis



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