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J. Lipid Res.
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A more recent version of this article appeared on April 1, 2009

Papers In Press, published online ahead of print December 17, 2008
J. Lipid Res., doi:10.1194/jlr.R800094-JLR200
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Submitted on November 24, 2008
Revised on December 8, 2008
Accepted on December 17, 2008

Prostanoids in health and disease

Emer M. Smyth, Tilo Grosser, Miao Wang, Ying Yu, and Garret A. FitzGerald

Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104

Corresponding Author: garret{at}exchange.upenn.edu

The prostanoids are a family of lipid mediators generated by the action of cyclooxygenase on a 20-carbon unsaturated fatty acid, arachidonic acid. Prostanoids are generated widely in response to diverse stimuli and, acting in a paracrine or autocrine manner, play important roles in normal physiology and disease. This review summarizes the current knowledge on prostanoid generation and the roles of individual mediators, their biosynthetic pathways and their receptors, in health and disease.


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JLR 50th Anniversary Collection
Anniversary Collection:: Lipids in Health and Disease

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