Journal of Lipid Research, Vol. 42, 155-155, August 2001
Copyright © 2001 by Lipid Research, Inc.
Erratum
ERRATUM
In the article "Novel mutations in the gene encoding ATP-binding cassette 1 in four Tangier disease kindreds"
Margaret E. Brousseau et al. published in the March 2000 issue of the
Journal of Lipid Research Volume 41, pages 433–441, the authors incorrectly reported the amino acid substitution in the TD18 kindred. The corrections shown below appear in boldface.
The G
A substitution, as shown in Table 2 on page 438, results in the replacement of an aspartic acid (Asp) residue with asparagine (Asn), not leucine (Leu). Therefore (AspAsn) should appear instead of (AspLeu). Additionally, in the Results section on page 437, four lines from the bottom in the right column, the sentence should read "This mutation causes a change of amino acid from aspartate to asparagine at codon 1229, resulting in the substitution of a negatively charged amino acid residue with an uncharged residue."
In a letter to the Editor, the authors state "Because this mutation involves a conserved amino acid (Asp) and results in the replacement of a negatively charged amino acid with an uncharged residue in the highly charged linker region, an important regulatory domain of ABCA1, this error does not change our conclusions about this mutation in any way. Moreover, we clearly identified this mutation on both alleles in each TD-18 subject, indicating homozygosity for this missense mutation."
The Journal of Lipid Research and the authors apologize for this error.
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