| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Lipid Research, Vol 34, 167-179, Copyright © 1993 by Lipid Research, Inc.
JL Dixon and HN Ginsberg
A major theme of this review is that apoB secretion is regulated post-
translationally, and that apoB secretion reacts rapidly to the current
state of lipid metabolism in the cell. Therefore, as discussed by Fungwe et
al. (122), the metabolism of triglyceride and of cholesteryl ester, in so
far as both can be used as core lipids for apoB-containing LPs, are
inextricably linked, and the shortage of one or both of these lipids could,
by "allowing" increased intracellular degradation in the ER, inhibit the
secretion of apoB. Another theme in this review is that the regulation of
apoB secretion may be quite different in rat hepatocytes compared to
cultured cells (HepG2) used as a model for human hepatocytes. Exogenous
fatty acids appear to modulate the rate of apoB secretion in HepG2 cells,
whereas they have only minimal effects on apoB secretion in rat hepatocytes
or liver. Increased dietary cholesterol, on the other hand, appears to be
an important modulator of apoB secretion in rats, but the evidence for
effects of cholesterol on apoB secretion in HepG2 cells is less convincing.
Finally, because HepG2 cells are an immortalized cell line, there could be
many differences between these cells and human hepatocytes in vivo.
Therefore, many of the results obtained with HepG2 cells should be
corroborated in primary cultures of human hepatocytes. However,
investigators utilizing primary human hepatocytes should be sure that the
culture conditions are adequate to maintain the continued transcription of
liver specific genes and to prevent the dedifferentiation of these cells in
culture (85, 86).
REVIEWS
Regulation of hepatic secretion of apolipoprotein B-containing lipoproteins: information obtained from cultured liver cells
Department of Food Science and Human Nutrition, University of Missouri, Columbia 65211.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Manchekar, P. E. Richardson, Z. Sun, Y. Liu, J. P. Segrest, and N. Dashti Charged Amino Acid Residues 997-1000 of Human Apolipoprotein B100 Are Critical for the Initiation of Lipoprotein Assembly and the Formation of a Stable Lipidated Primordial Particle in McA-RH7777 Cells J. Biol. Chem., October 24, 2008; 283(43): 29251 - 29265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Wei, M. Alam, F. Sun, L. B. Agellon, D. E. Vance, and R. Lehner Apolipoprotein B and triacylglycerol secretion in human triacylglycerol hydrolase transgenic mice J. Lipid Res., December 1, 2007; 48(12): 2597 - 2606. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Fantuzzi and T. Mazzone Adipose Tissue and Atherosclerosis: Exploring the Connection Arterioscler. Thromb. Vasc. Biol., May 1, 2007; 27(5): 996 - 1003. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Tsai, W. Qiu, R. Kohen-Avramoglu, and K. Adeli MEK-ERK Inhibition Corrects the Defect in VLDL Assembly in HepG2 Cells: Potential Role of ERK in VLDL-ApoB100 Particle Assembly Arterioscler. Thromb. Vasc. Biol., January 1, 2007; 27(1): 211 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Millar, S. J. Stone, U. J. F. Tietge, B. Tow, J. T. Billheimer, J. S. Wong, R. L. Hamilton, R. V. Farese Jr., and D. J. Rader Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production J. Lipid Res., October 1, 2006; 47(10): 2297 - 2305. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Peluso Flavonoids Attenuate Cardiovascular Disease, Inhibit Phosphodiesterase, and Modulate Lipid Homeostasis in Adipose Tissue and Liver Experimental Biology and Medicine, September 1, 2006; 231(8): 1287 - 1299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Aravindhan, C. L. Webb, M. Jaye, A. Ghosh, R. N. Willette, N. J. DiNardo, and B. M. Jucker Assessing the effects of LXR agonists on cellular cholesterol handling: a stable isotope tracer study J. Lipid Res., June 1, 2006; 47(6): 1250 - 1260. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-H. Yu and H. N. Ginsberg Adipocyte Signaling and Lipid Homeostasis: Sequelae of Insulin-Resistant Adipose Tissue Circ. Res., May 27, 2005; 96(10): 1042 - 1052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Repa, S. D. Turley, G. Quan, and J. M. Dietschy Delineation of molecular changes in intrahepatic cholesterol metabolism resulting from diminished cholesterol absorption J. Lipid Res., April 1, 2005; 46(4): 779 - 789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Liang, P. Oelkers, C. Guo, P.-C. Chu, J. L. Dixon, H. N. Ginsberg, and S. L. Sturley Overexpression of Human Diacylglycerol Acyltransferase 1, Acyl-CoA:Cholesterol Acyltransferase 1, or Acyl-CoA:Cholesterol Acyltransferase 2 Stimulates Secretion of Apolipoprotein B-containing Lipoproteins in McA-RH7777 Cells J. Biol. Chem., October 22, 2004; 279(43): 44938 - 44944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Ganji, S. Tavintharan, D. Zhu, Y. Xing, V. S. Kamanna, and M. L. Kashyap Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells J. Lipid Res., October 1, 2004; 45(10): 1835 - 1845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-L. Zhang, A. Hernandez-Ono, C. Ko, K. Yasunaga, L.-S. Huang, and H. N. Ginsberg Regulation of Hepatic Apolipoprotein B-lipoprotein Assembly and Secretion by the Availability of Fatty Acids: I. DIFFERENTIAL RESPONSE TO THE DELIVERY OF FATTY ACIDS VIA ALBUMIN OR REMNANT-LIKE EMULSION PARTICLES J. Biol. Chem., April 30, 2004; 279(18): 19362 - 19374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Alam, M. Stolinski, C. Pentecost, M. A. Boroujerdi, R. H. Jones, P. H. Sonksen, and A. M. Umpleby The Effect of a Six-Month Exercise Program on Very Low-Density Lipoprotein Apolipoprotein B Secretion in Type 2 Diabetes J. Clin. Endocrinol. Metab., February 1, 2004; 89(2): 688 - 694. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zoltowska, E. Ziv, E. Delvin, D. Sinnett, R. Kalman, C. Garofalo, E. Seidman, and E. Levy Cellular Aspects of Intestinal Lipoprotein Assembly in Psammomys Obesus: A Model of Insulin Resistance and Type 2 Diabetes Diabetes, October 1, 2003; 52(10): 2539 - 2545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. H. C. M. T. Prinsen, J. A. Romijn, P. H. Bisschop, M. M. J. de Barse, P. H. R. Barrett, M. Ackermans, R. Berger, T. J. Rabelink, and M. G. M. de Sain-van der Velden Endogenous cholesterol synthesis is associated with VLDL-2 apoB-100 production in healthy humans J. Lipid Res., July 1, 2003; 44(7): 1341 - 1348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-s. Liang, T. Kim, S. Fang, J. Yamaguchi, A. M. Weissman, E. A. Fisher, and H. N. Ginsberg Overexpression of the Tumor Autocrine Motility Factor Receptor Gp78, a Ubiquitin Protein Ligase, Results in Increased Ubiquitinylation and Decreased Secretion of Apolipoprotein B100 in HepG2 Cells J. Biol. Chem., June 20, 2003; 278(26): 23984 - 23988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang and H. Herscovitz Nascent Lipidated Apolipoprotein B Is Transported to the Golgi as an Incompletely Folded Intermediate as Probed by Its Association with Network of Endoplasmic Reticulum Molecular Chaperones, GRP94, ERp72, BiP, Calreticulin, and Cyclophilin B J. Biol. Chem., February 21, 2003; 278(9): 7459 - 7468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kummrow, M. M. Hussain, M. Pan, J. B. Marsh, and E. A. Fisher Myristic acid increases dense lipoprotein secretion by inhibiting apoB degradation and triglyceride recruitment J. Lipid Res., December 1, 2002; 43(12): 2155 - 2163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Attie, R. M. Krauss, M. P. Gray-Keller, A. Brownlie, M. Miyazaki, J. J. Kastelein, A. J. Lusis, A. F. H. Stalenhoef, J. P. Stoehr, M. R. Hayden, et al. Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia J. Lipid Res., November 1, 2002; 43(11): 1899 - 1907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Singh, O. A. Batuman, H. O. Akman, M. H. Kedees, V. Vakil, and M. M. Hussain Differential, Tissue-specific, Transcriptional Regulation of Apolipoprotein B Secretion by Transforming Growth Factor beta J. Biol. Chem., October 11, 2002; 277(42): 39515 - 39524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Riddle, N. M. Schildmeyer, C. Phan, C. J. Fichtenbaum, and D. Y. Hui The HIV protease inhibitor ritonavir increases lipoprotein production and has no effect on lipoprotein clearance in mice J. Lipid Res., September 1, 2002; 43(9): 1458 - 1463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Xie, L. A. Woollett, S. D. Turley, and J. M. Dietschy Fatty acids differentially regulate hepatic cholesteryl ester formation and incorporation into lipoproteins in the liver of the mouse J. Lipid Res., September 1, 2002; 43(9): 1508 - 1519. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Ferguson, E. L. LeCluyse, M. Negishi, and J. A. Goldstein Regulation of Human CYP2C9 by the Constitutive Androstane Receptor: Discovery of a New Distal Binding Site Mol. Pharmacol., September 1, 2002; 62(3): 737 - 746. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Dashti, Q. Feng, M. R. Freeman, M. Gandhi, and F. A. Franklin Trans Polyunsaturated Fatty Acids Have More Adverse Effects than Saturated Fatty Acids on the Concentration and Composition of Lipoproteins Secreted by Human Hepatoma HepG2 Cells J. Nutr., September 1, 2002; 132(9): 2651 - 2659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nishimaki-Mogami, Z. Yao, and K. Fujimori Inhibition of phosphatidylcholine synthesis via the phosphatidylethanolamine methylation pathway impairs incorporation of bulk lipids into VLDL in cultured rat hepatocytes J. Lipid Res., July 1, 2002; 43(7): 1035 - 1045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Fisher and H. N. Ginsberg Complexity in the Secretory Pathway: The Assembly and Secretion of Apolipoprotein B-containing Lipoproteins J. Biol. Chem., May 10, 2002; 277(20): 17377 - 17380. [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Dixon, J. Biddle, C.-m. Lo, J. D. Stoops, H. Li, N. Sakata, and T. E. Phillips Apolipoprotein B Is Synthesized in Selected Human Non-hepatic Cell Lines But Not Processed into Mature Lipoprotein J. Histochem. Cytochem., May 1, 2002; 50(5): 629 - 640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sakata, T. E. Phillips, and J. L. Dixon Distribution, transport, and degradation of apolipoprotein B-100 in HepG2 cells J. Lipid Res., December 1, 2001; 42(12): 1947 - 1958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Siri, N. Candela, Y.-L. Zhang, C. Ko, S. Eusufzai, H. N. Ginsberg, and L.-S. Huang Post-transcriptional Stimulation of the Assembly and Secretion of Triglyceride-rich Apolipoprotein B Lipoproteins in a Mouse with Selective Deficiency of Brown Adipose Tissue, Obesity, and Insulin Resistance J. Biol. Chem., November 30, 2001; 276(49): 46064 - 46072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. McConihay, P. S. Horn, and L. A. Woollett Effect of maternal hypercholesterolemia on fetal sterol metabolism in the Golden Syrian hamster J. Lipid Res., July 1, 2001; 42(7): 1111 - 1119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ko, T.-L. Lee, P. W. Lau, J. Li, B. T. Davis, E. Voyiaziakis, D. B. Allison, S. C. Chua , Jr., and L.-S. Huang Two novel quantitative trait loci on mouse chromosomes 6 and 4 independently and synergistically regulate plasma apoB levels J. Lipid Res., May 1, 2001; 42(5): 844 - 855. [Abstract] [Full Text]
|
|
|
|
|
|
L. L. Swift, K. Valyi-Nagy, C. Rowland, and C. Harris Assembly of very low density lipoproteins in mouse liver: evidence of heterogeneity of particle density in the Golgi apparatus J. Lipid Res., February 1, 2001; 42(2): 218 - 224. [Abstract] [Full Text]
|
|
|
|
|
|
N. Dashti, Q. Feng, and F. A. Franklin Long-term effects of cis and trans monounsaturated (18:1) and saturated (16:0) fatty acids on the synthesis and secretion of apolipoprotein A-I- and apolipoprotein B-containing lipoproteins in HepG2 cells J. Lipid Res., December 1, 2000; 41(12): 1980 - 1990. [Abstract] [Full Text]
|
|
|
|
|
|
F. H. A. F. de Man, I. J. A. M. Jonkers, E. Schwedhelm, A. H. M. Smelt, W. Onkenhout, W. van Duyvenvoorde, R. Buytenhek, J. A. G. Leuven, R. Troost, A. van der Laarse, et al. Normal Oxidative Stress and Enhanced Lipoprotein Resistance to In Vitro Oxidation in Hypertriglyceridemia : Effects of Bezafibrate Therapy Arterioscler. Thromb. Vasc. Biol., November 1, 2000; 20(11): 2434 - 2440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. V. Chirieac, L. R. Chirieac, J. P. Corsetti, J. Cianci, C. E. Sparks, and J. D. Sparks Glucose-stimulated insulin secretion suppresses hepatic triglyceride-rich lipoprotein and apoB production Am J Physiol Endocrinol Metab, November 1, 2000; 279(5): E1003 - E1011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. G. Parhofer, P. H. R. Barrett, T. Demant, and P. Schwandt Acute effects of low density lipoprotein apheresis on metabolic parameters of apolipoprotein B J. Lipid Res., October 1, 2000; 41(10): 1596 - 1603. [Abstract] [Full Text]
|
|
|
|
|
|
X. F. Huang and G. S. Shelness Efficient glycosylation site utilization by intracellular apolipoprotein B: implications for proteasomal degradation J. Lipid Res., December 1, 1999; 40(12): 2212 - 2222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Mahley, Y. Huang, and S. C. Rall , Jr. Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia): questions, quandaries, and paradoxes J. Lipid Res., November 1, 1999; 40(11): 1933 - 1949. [Abstract] [Full Text]
|
|
|
|
|
|
E. Voyiaziakis, C. Ko, S. M. O'Rourke, and L.-S. Huang Genetic control of hepatic apoB-100 secretion in human apoB transgenic mouse strains J. Lipid Res., November 1, 1999; 40(11): 2004 - 2012. [Abstract] [Full Text]
|
|
|
|
|
|
A.-M. Hebbachi, A.-M. Brown, and G. F. Gibbons Suppression of cytosolic triacylglycerol recruitment for very low density lipoprotein assembly by inactivation of microsomal triglyceride transfer protein results in a delayed removal of apoB-48 and apoB-100 from microsomal and Golgi membranes of primary rat hepatocytes J. Lipid Res., October 1, 1999; 40(10): 1758 - 1768. [Abstract] [Full Text]
|
|
|
|
|
|
F. M. van 't Hooft, S. Jormsjö, B. Lundahl, P. Tornvall, P. Eriksson, and A. Hamsten A functional polymorphism in the apolipoprotein B promoter that influences the level of plasma low density lipoprotein J. Lipid Res., September 1, 1999; 40(9): 1686 - 1694. [Abstract] [Full Text]
|
|
|
|
|
|
J.-P. Wang, M. Enjoji, M. Tiebel, S. Ochsner, L. Chan, and B.-B. Teng Hammerhead Ribozyme Cleavage of Apolipoprotein B mRNA Generates a Truncated Protein J. Biol. Chem., August 20, 1999; 274(34): 24161 - 24170. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Berger and R. J. Barnard Effect of diet on fat cell size and hormone-sensitive lipase activity J Appl Physiol, July 1, 1999; 87(1): 227 - 232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Burnett, L. J. Wilcox, D. E. Telford, S. J. Kleinstiver, P. H. R. Barrett, R. S. Newton, and M. W. Huff Inhibition of ACAT by avasimibe decreases both VLDL and LDL apolipoprotein B production in miniature pigs J. Lipid Res., July 1, 1999; 40(7): 1317 - 1328. [Abstract] [Full Text]
|
|
|
|
|
|
N. Sakata, J. D. Stoops, and J. L. Dixon Cytosolic Components Are Required for Proteasomal Degradation of Newly Synthesized Apolipoprotein B in Permeabilized HepG2 Cells J. Biol. Chem., June 11, 1999; 274(24): 17068 - 17074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Wilcox, P. H. R. Barrett, R. S. Newton, and M. W. Huff ApoB100 Secretion From HepG2 Cells is Decreased by the ACAT Inhibitor CI-1011 : An Effect Associated With Enhanced Intracellular Degradation of ApoB Arterioscler. Thromb. Vasc. Biol., April 1, 1999; 19(4): 939 - 949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F.-Y. Jin, V. S. Kamanna, and M. L. Kashyap Niacin Accelerates Intracellular ApoB Degradation by Inhibiting Triacylglycerol Synthesis in Human Hepatoblastoma (HepG2) Cells Arterioscler. Thromb. Vasc. Biol., April 1, 1999; 19(4): 1051 - 1059. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-M. Brown, D. Wiggins, and G. F. Gibbons Glucose Phosphorylation Is Essential for the Turnover of Neutral Lipid and the Second Stage Assembly of Triacylglycerol-Rich ApoB-Containing Lipoproteins in Primary Hepatocyte Cultures Arterioscler. Thromb. Vasc. Biol., February 1, 1999; 19(2): 321 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. R. Christ, M. H. Cummings, E. Albany, A. M. Umpleby, P. J. Lumb, A. S. Wierzbicki, R. P. Naoumova, M. A. Boroujerdi, P. H. Sönksen, and D. L. Russell-Jones Effects of Growth Hormone (GH) Replacement Therapy on Very Low Density Lipoprotein Apolipoprotein B100 Kinetics in Patients with Adult GH Deficiency: A Stable Isotope Study J. Clin. Endocrinol. Metab., January 1, 1999; 84(1): 307 - 316. [Abstract] [Full Text]
|
|
|
|
|
|
J.-s. Liang, X. Wu, H. Jiang, M. Zhou, H. Yang, P. Angkeow, L.-S. Huang, S. L. Sturley, and H. Ginsberg Translocation Efficiency, Susceptibility to Proteasomal Degradation, and Lipid Responsiveness of Apolipoprotein B Are Determined by the Presence of beta Sheet Domains J. Biol. Chem., December 25, 1998; 273(52): 35216 - 35221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Cavallo, R. S. McLeod, D. Rudy, A. Aiton, Z. Yao, and K. Adeli Intracellular Translocation and Stability of Apolipoprotein B Are Inversely Proportional to the Length of the Nascent Polypeptide J. Biol. Chem., December 11, 1998; 273(50): 33397 - 33405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Mitchell, M. Zhou, R. Pariyarath, H. Wang, J. D. Aitchison, H. N. Ginsberg, and E. A. Fisher Apoprotein B100 has a prolonged interaction with the translocon during which its lipidation and translocation change from dependence on the microsomal triglyceride transfer protein to independence PNAS, December 8, 1998; 95(25): 14733 - 14738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Wang, T. Arai, Y. Ji, F. Rinninger, and A. R. Tall Liver-specific Overexpression of Scavenger Receptor BI Decreases Levels of Very Low Density Lipoprotein ApoB, Low Density Lipoprotein ApoB, and High Density Lipoprotein in Transgenic Mice J. Biol. Chem., December 4, 1998; 273(49): 32920 - 32926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Jiang, H. N. Ginsberg, and X. Wu Glucose does not stimulate apoprotein B secretion from HepG2 cells because of insufficient stimulation of triglyceride synthesis J. Lipid Res., November 1, 1998; 39(11): 2277 - 2285. [Abstract] [Full Text]
|
|
|
|
|
|
W. Liao, S.-C. J. Yeung, and L. Chan Proteasome-mediated Degradation of Apolipoprotein B Targets Both Nascent Peptides Cotranslationally Before Translocation and Full-length Apolipoprotein B After Translocation into the Endoplasmic Reticulum J. Biol. Chem., October 16, 1998; 273(42): 27225 - 27230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Cases, S. Novak, Y.-W. Zheng, H. M. Myers, S. R. Lear, E. Sande, C. B. Welch, A. J. Lusis, T. A. Spencer, B. R. Krause, et al. ACAT-2, A Second Mammalian Acyl-CoA:Cholesterol Acyltransferase. ITS CLONING, EXPRESSION, AND CHARACTERIZATION J. Biol. Chem., October 9, 1998; 273(41): 26755 - 26764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Jamil, C.-H. Chu, J. K . Dickson , Jr., Y. Chen, M. Yan, S. A. Biller, R. E. Gregg, J. R. Wetterau, and D. A. Gordon Evidence that microsomal triglyceride transfer protein is limiting in the production of apolipoprotein B-containing lipoproteins in hepatic cells J. Lipid Res., July 1, 1998; 39(7): 1448 - 1454. [Abstract] [Full Text]
|
|
|
