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Journal of Lipid Research, Vol 38, 2249-2263, Copyright © 1997 by Lipid Research, Inc.
DL Brasaemle, T Barber, NE Wolins, G Serrero, EJ Blanchette-Mackie and C Londos
The adipose differentiation-related protein (ADRP) was first characterized
as a mRNA induced early during adipocyte differentiation (Jiang, H. P., and
G. Serrero. 1992. Proc. Natl. Acad. Sci. USA. 89:7856-7860). The present
study demonstrates that ADRP mRNA is expressed in a variety of tissues and
cultured cell lines. Immunocytochemical examination revealed that ADRP
localizes to neutral lipid storage droplets in cultured murine 3T3-L1
adipocytes, murine MA- 10 Leydig cells, Chinese hamster ovary (CHO)
fibroblasts, and human HepG2 hepatoma cells; the association of ADRP with
lipid droplets was confirmed by subcellular fractionation of MA-10 Leydig
cells. In addition to ADRP, steroidogenic cells and adipocytes express the
perilipins, a family of lipid droplet-associated proteins that share a
highly related sequence domain with ADRP. ADRP and perilipins co- localize
on lipid droplets in MA-10 Leydig cells. While ADRP was found on small
lipid droplets in 3T3-L1 preadipocytes and early differentiated adipocytes,
it was absent in maturing adipocytes. In contrast, perilipins were absent
early during differentiation, but were found on small and large lipid
droplets at later stages. The transition in surface protein composition of
adipocyte lipid droplets from ADRP to perilipins occurred 3 days after the
initiation of differentiation when cells displayed co-localizatioin of both
proteins on the same lipid droplets. The specific localization of adipose
differentiation-related protein to lipid droplets in a wide variety of
cells suggests that ADRP plays a role in management of neutral lipid
stores.
ARTICLES
Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein
Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-2715, USA.
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