J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1194/jlr.M300217-JLR200 on July 1, 2003

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
M300217-JLR200v1
44/10/1984    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Song, C.
Right arrow Articles by Horrobin, D. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Song, C.
Right arrow Articles by Horrobin, D. F.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Journal of Lipid Research, Vol. 44, 1984-1991, October 2003
Copyright © 2003 by American Society for Biochemistry and Molecular Biology

Effects of dietary n-3 or n-6 fatty acids on interleukin-1ß-induced anxiety, stress, and inflammatory responses in rats

Cai Song1,*, Xuwen Li*, Brian E. Leonard{dagger} and David F. Horrobin2,§

* Department of Psychiatry, University of British Columbia, Canada
{dagger} Brain and Behaviour Research Institute, Academic Hospital Maastricht, University of Maastricht, The Netherlands
§ Laxdale Research, Stirling, Scotland, UK

1 To whom correspondence should be addressed. e-mail: caisong{at}interchange.ubc.ca

The present study demonstrated that an {omega} (n)-3 fatty acid, ethyl-eicosapentaenoic acid (ethyl-EPA), supplemented diet significantly attenuated the stress/anxiety behavior of rats in the "open field" and elevated plus maze, which was induced by subchronic intracerebroventricular administration of proinflammatory cytokine interleukin (IL)-1ß. Ethyl-EPA also reduced the rise in serum corticosterone induced by IL-1. The n-6 fatty acid ethyl-{gamma}-linolenic acid (ethyl-GLA) had little effect on the IL-1-induced changes in behavior and the corticosterone concentration. Following IL-1ß administration, ethyl-EPA reduced the elevated prostaglandin (PG) E2 secretion and increased the secretion of antiinflammatory cytokine IL-10 from whole blood cells. Ethyl-GLA showed a similar antiinflammatory effect to ethyl-EPA. By contrast, n-6 fatty acid arachidonic acid (AA) had no effect on the behavior, immune, and endocrine changes induced by IL-1. AA alone enhanced the basal inflammatory response, raised serum corticosterone concentrations, and induced anxiety behavior in the elevated plus maze. The reduced growth rates of rats following the administration of IL-1 was attenuated by ethyl-EPA, and to a greater extent by ethyl-EPA plus ethyl-GLA, but not by AA alone or in combination with ethyl-EPA.

Thus, ethyl-EPA would appear to antagonise the endocrine, immune, and behavioral effects of subchronic IL-1 administration. Ethyl-GLA only antagonised IL-1-induced inflammatory changes, whereas AA caused an increase in the secretion of corticosterone and PGE2, and induced anxiety-like behavior without enhancing the effects of IL-1.

Abbreviations: AA, arachidonic acid; EPA, eicosapentaenoic acid; GLA, {gamma}-linolenic acid; IL, interleukin; PGE2, prostaglandin E2

Supplementary key words eicosapentaenoic acid • {gamma}-linolenic acid • arachidonic acid • phospholipid supplementation • open field • inflammation • prostaglandin E2 • interleukin-10


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Nutr.Home page
C. Song, M. S. Manku, and D. F. Horrobin
Long-Chain Polyunsaturated Fatty Acids Modulate Interleukin-1{beta}-Induced Changes in Behavior, Monoaminergic Neurotransmitters, and Brain Inflammation in Rats
J. Nutr., May 1, 2008; 138(5): 954 - 963.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. E. Loscher, E. Draper, O. Leavy, D. Kelleher, K. H. G. Mills, and H. M. Roche
Conjugated Linoleic Acid Suppresses NF-{kappa}B Activation and IL-12 Production in Dendritic Cells through ERK-Mediated IL-10 Induction
J. Immunol., October 15, 2005; 175(8): 4990 - 4998.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
A. T Merchant, G. C Curhan, E. B Rimm, W. C Willett, and W. W Fawzi
Intake of n-6 and n-3 fatty acids and fish and risk of community-acquired pneumonia in US men
Am. J. Clinical Nutrition, September 1, 2005; 82(3): 668 - 674.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
C. Song and D. Horrobin
Omega-3 fatty acid ethyl-eicosapentaenoate, but not soybean oil, attenuates memory impairment induced by central IL-1{beta} administration
J. Lipid Res., June 1, 2004; 45(6): 1112 - 1121.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2003 by the American Society for Biochemistry and Molecular Biology.