HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: R300010-JLR200v1 44/11/2019    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chauhan, N. B. Search for Related Content PubMed PubMed Citation Articles by Chauhan, N. B. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 44, 2019-2029, November 2003
Copyright © 2003 by American Society for Biochemistry and Molecular Biology

Thematic Review

Membrane dynamics, cholesterol homeostasis, and Alzheimer's disease

Neelima B. Chauhan¹

Research and Development, Veterans Affairs Chicago Health Care System–West Side VA Medical Center, Chicago, IL 60612
Department of NeuroAnesthesiology, University of Illinois at Chicago, Chicago, IL 60612

¹ To whom correspondence should be addressed. e-mail: nchauhan{at}uic.edu

Alzheimer's disease (AD) is characterized by the deposition of ß-amyloid (Aß) plaques derived from the amyloidogenic processing; of a transmembrane protein called ß-amyloid precursor protein (APP). In addition to the known genetic/sporadic factors that promote the formation of Aß, the composition and structural dynamics of the membrane are also thought to play a significant role in the amyloidogenic processing of APP that promotes seeding of Aß.

This minireview reinforces the roles played by membrane dynamics, membrane microdomains, and cholesterol homeostasis in relation to amyloidogenesis, and reviews current strategies of lowering cholesterol in treating AD.

Supplementary key words ß-amyloid precursor • protein processing • lipid raft • caveolae • glycophosphatidylinositol • apolipoprotein E

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				V. Paul, H. H. D. Meyer, K. Leidl, S. Soumian, and C. Albrecht A novel enzyme immunoassay specific for ABCA1 protein quantification in human tissues and cells J. Lipid Res., October 1, 2008; 49(10): 2259 - 2267. [Abstract] [Full Text] [PDF]

				D. B. Goodenowe, L. L. Cook, J. Liu, Y. Lu, D. A. Jayasinghe, P. W. K. Ahiahonu, D. Heath, Y. Yamazaki, J. Flax, K. F. Krenitsky, et al. Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia J. Lipid Res., November 1, 2007; 48(11): 2485 - 2498. [Abstract] [Full Text] [PDF]

				K.-i. Okuhira, M. L. Fitzgerald, D. A. Sarracino, J. J. Manning, S. A. Bell, J. L. Goss, and M. W. Freeman Purification of ATP-binding Cassette Transporter A1 and Associated Binding Proteins Reveals the Importance of {beta}1-Syntrophin in Cholesterol Efflux J. Biol. Chem., November 25, 2005; 280(47): 39653 - 39664. [Abstract] [Full Text] [PDF]

				C.-Y. Chou, Y.-L. Lin, Y.-C. Huang, S.-Y. Sheu, T.-H. Lin, H.-J. Tsay, G.-G. Chang, and M.-S. Shiao Structural Variation in Human Apolipoprotein E3 and E4: Secondary Structure, Tertiary Structure, and Size Distribution Biophys. J., January 1, 2005; 88(1): 455 - 466. [Abstract] [Full Text] [PDF]

				M. Mohr, M. Klempt, B. Rathkolb, M. H. de Angelis, E. Wolf, and B. Aigner Hypercholesterolemia in ENU-induced mouse mutants J. Lipid Res., November 1, 2004; 45(11): 2132 - 2137. [Abstract] [Full Text] [PDF]

				D. E. Hansel, A. Rahman, M. House, R. Ashfaq, K. Berg, C. J. Yeo, and A. Maitra Met Proto-Oncogene and Insulin-Like Growth Factor Binding Protein 3 Overexpression Correlates with Metastatic Ability in Well-Differentiated Pancreatic Endocrine Neoplasms Clin. Cancer Res., September 15, 2004; 10(18): 6152 - 6158. [Abstract] [Full Text] [PDF]