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Originally published In Press as doi:10.1194/jlr.M300124-JLR200 on August 16, 2003

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Journal of Lipid Research, Vol. 44, 2059-2064, November 2003
Copyright © 2003 by American Society for Biochemistry and Molecular Biology

The influence of the apolipoprotein E gene promoter (-219G/ T) polymorphism on postprandial lipoprotein metabolism in young normolipemic males

Juan Antonio Moreno*, José López-Miranda*, Carmen Marín*, Purificación Gómez*, Pablo Pérez-Martínez*, Francisco Fuentes*, Rafael Angel Fernández de la Puebla*, Juan Antonio Paniagua*, José María Ordovas{dagger} and Francisco Pérez-Jiménez1,*

* Lipids and Atherosclerosis Research Unit, Hospital Reina Sofía University, Córdoba, Spain
{dagger} Jean Mayer-United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111-1524

1 To whom correspondence should be addressed. e-mail: fperezjimenez{at}uco.es

The apolipoprotein E (apoE) gene promoter (-219G/T) polymorphism has been associated with increased risk of myocardial infarction, premature coronary heart disease, and decreased plasma apoE concentrations. We examined whether the -219G/T polymorphism could modify the postprandial response of triacylglycerol-rich lipoproteins (TRLs). Fifty-one healthy apoE 3/3 male volunteers (14GG, 29GT, and 8TT) were given a vitamin A fat-loading test consisting of 1 g of fat/kg body weight and 60,000 IU of vitamin A per m2 of body surface area. Blood samples were taken at time 0 and every hour until the sixth hour, and every 2 hours and 30 minutes until the eleventh hour. Cholesterol, triacylglycerols (TGs), and apoE were determined in plasma; and cholesterol, TG, apoB-100, apoB-48, and retinyl palmitate (RP) were analyzed in lipoprotein fractions. Postprandial lipemia data revealed that subjects with the -219TT genotype had a higher postprandial response of large TRL-cholesterol (P < 0.03), large TRL-triacylglycerols (P < 0.001), large TRL-RP (P < 0.004), and small TRL-apoB-48 (P < 0.03) than carriers of the -219G allele. Moreover, the -219TT subjects had the lowest postprandial levels of serum apoE (P < 0.05).

In conclusion, the -219G/T polymorphism may influence TRL metabolism during the postprandial period, thus prolonging postprandial lipemia in subjects with the TT genotype.

Supplementary key words postprandial lipemia • triacylglycerols • retinyl palmitate • cholesterol • triacylglycerol-rich lipoproteins


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