J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1194/jlr.M300233-JLR200 on September 1, 2003

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
M300233-JLR200v1
44/12/2356    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jang, Y.
Right arrow Articles by Lee, J. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jang, Y.
Right arrow Articles by Lee, J. H.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Journal of Lipid Research, Vol. 44, 2356-2364, December 2003
Copyright © 2003 by American Society for Biochemistry and Molecular Biology

Visceral fat accumulation determines postprandial lipemic response, lipid peroxidation, DNA damage, and endothelial dysfunction in nonobese Korean men

Yangsoo Jang*,{dagger}, Oh Yoen Kim{dagger}, Ha Jung Ryu§, Ji Young Kim§, Sang Hoon Song**, Jose M. Ordovas{dagger}{dagger} and Jong Ho Lee1,{dagger},§

* Division of Cardiology, Cardiovascular Genome Center, Yonsei Medical Institute, Yonsei University, Seoul, 120-749 Korea
{dagger} Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, 120-749 Korea
§ Department of Food & Nutrition, Yonsei University, Seoul, 120-749 Korea
** Food Ingredient Division, Foods R&D Center, CJ Corp., Seoul, Korea
{dagger}{dagger} Nutrition and Genomics Laboratory,, JM-USDA-HNRCA, Tufts University, Boston, MA 02111

1 To whom correspondence should be addressed. e-mail: jhleeb{at}yonsei.ac.kr

Visceral fat has been associated with multiple cardiovascular disease (CVD) risk factors. The aim of this study was to identify anthropometrical measures most closely associated with some well-known CVD risk factors. Because most Asians at risk have normal body mass index (BMI) according to Western standards, we studied healthy nonobese Korean males (n = 102; age: 36.5 ± 0.8 years, BMI: 23.8 ± 0.2 kg/m2). Visceral fat area (VFA) at the fourth lumbar vertebra was associated with increased postprandial triglyceride (TG) response (r = 0.53, P < 0.001) and with plasma malondialdehyde (MDA) (r = 0.36, P < 0.01) and PGF2{alpha} (r = 0.24, P < 0.05). When matched for BMI and age, men with high VFA (HVFA) (>=100 cm2; n = 27) had higher blood pressure (P < 0.01), increased consumption of cigarettes (P < 0.01), and lower ratio of energy expenditure to calorie intake (P < 0.01) as compared with low VFA men (<100 cm2; n = 27). Men with HVFA showed higher TG, glucose, and insulin responses following fat and oral glucose tolerance tests respectively higher plasma concentrations of MDA (P < 0.001), urinary PGF2{alpha} (P < 0.05), and lymphocytes deoxyribonucleic acid tail moments (P < 0.01). Conversely, HVFA was associated with lower testosterone, insulin-like growth factor-1, and brachial artery flow-mediated dilation (P < 0.001).

In conclusion, our data indicate that visceral fat accumulation, even in nonobese men, is a major factor contributing to increased CVD risk.

Supplementary key words flow-mediated dilation • body fat distribution • glucose tolerance


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J AndrolHome page
A. M. Traish, F. Saad, and A. Guay
The Dark Side of Testosterone Deficiency: II. Type 2 Diabetes and Insulin Resistance
J Androl, January 1, 2009; 30(1): 23 - 32.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. A. Phillips, O. A. Hatoum, and D. D. Gutterman
The mechanism of flow-induced dilation in human adipose arterioles involves hydrogen peroxide during CAD
Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H93 - H100.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
Y. Jang, J. Y. Kim, O. Y. Kim, J. E. Lee, H. Cho, J. M Ordovas, and J. H. Lee
The -1131T->C polymorphism in the apolipoprotein A5 gene is associated with postprandial hypertriacylglycerolemia; elevated small, dense LDL concentrations; and oxidative stress in nonobese Korean men
Am. J. Clinical Nutrition, October 1, 2004; 80(4): 832 - 840.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2003 by the American Society for Biochemistry and Molecular Biology.