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Journal of Lipid Research, Vol. 44, 430-436, February 2003
Copyright © 2003 by Lipid Research, Inc.

Biological and genetic determinants of serum apoC-III concentration

Peggy Tilly, Catherine Sass, Monique Vincent-Viry, Dominique Aguillon, Gérard Siest¹ and Sophie Visvikis

Institut National de Santé et de Recherche Médicale U525, Centre de Médecine Préventive, 2 Avenue du Doyen J. Parisot, F54500 Vandoeuvre-Lès-Nancy, France

¹ To whom correspondence should be addressed. e-mail: gerard.siest{at}cmp.u-nancy.fr

Apolipoprotein C-III (apoC-III) is involved in triglycerides metabolism, and is therefore important for the pathogenesis of coronary heart diseases. However, to our knowledge serum apoC-III variation factors and reference limits have never been determined, so the aim of this study was to establish them and facilitate clinical usefulness. We measured serum apoC-III concentration of apparently healthy subjects of the Stanislas Cohort by an immunoturbidimetric method. Genetic polymorphisms within the APOC3, APOE, APOAIV, and LPL genes were determined by a multiplex PCR. Serum apoC-III concentration varied from 28.2 mg/l to 225.8 mg/l in the overall sample and between subjects variability was about 30%. Factors influencing apoC-III concentration were age, BMI in adult men, alcohol consumption in adults, oral contraceptive intake in women, the post-pubescent status in boys.

The APOC3 1100T allele in adult men and the APOC3 -455C allele in boys were associated with increased apoC-III concentration. The APOA4 360His allele was associated with decreased apoC-III concentration in women. We also established reference limits of serum apoC-III concentration according to age and gender.

Supplementary key words apolipoproteins • lipids • reference values • polymorphism

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