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Journal of Lipid Research, Vol. 44, 522-526, March 2003
Copyright © 2003 by Lipid Research, Inc.

Single session exercise stimulates formation of preß₁-HDL in leg muscle

Dmitri Sviridov¹, Bronwyn Kingwell, Anh Hoang, Anthony Dart and Paul Nestel

Wynn Domain, Baker Medical Research Institute, PO Box 6492 St. Kilda Rd. Central, Melbourne, Victoria, 8008, Australia

¹ To whom correspondence should be addressed. e-mail: dmitri.sviridov{at}baker.edu.au

Physical activity can raise the level of circulating HDL cholesterol. Preß₁-HDL is thought to be either the initial acceptor of cellular cholesterol or virtually the first particle in the pathway of the formation of HDL from apolipoprotein A-I and cellular lipids. We have therefore sought to identify preß₁-HDL in arterial and venous circulations of exercising legs in healthy individuals and in subjects with stable Type 2 diabetes mellitus. Blood samples were taken simultaneously from the femoral artery and vein before and after 25 min cycling exercise. The major findings were, first, that exercise significantly increased plasma concentration of preß₁-HDL (20% increase, P < 0.05) and second, that the preß₁-HDL concentration was significantly higher in the venous compared with the arterial blood both before and after exercise in both diabetics and controls.

In the combined population, formation of preß₁-HDL at rest was 9.9 ± 5.2 mg/min and exercise enhanced preß₁-HDL formation 6.6-fold in both groups.

Abbreviations: CETP, cholesteryl ester transfer protein; LBF, leg blood flow; LPL, lipoprotein lipase; PLTP, phospholipid transfer protein; RCT, reverse cholesterol transport; TRL, triglyceride-rich lipoproteins

Supplementary key words reverse cholesterol transport • high density lipoprotein • cholesterol • atherosclerosis

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