J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
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Originally published In Press as doi:10.1194/jlr.M400148-JLR200 on October 1, 2004

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Journal of Lipid Research, Vol. 45, 2221-2226, December 2004
Copyright © 2004 by American Society for Biochemistry and Molecular Biology

Apolipoprotein E gene polymorphisms and thrombosis and restenosis after coronary artery stenting

Werner Koch1,*, Julinda Mehilli*, Arne Pfeufer{dagger},§, Albert Schömig* and Adnan Kastrati*

* Deutsches Herzzentrum München and 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, München, Germany
{dagger} Institut für Humangenetik, Klinikum rechts der Isar, Technische Universität München, München, Germany
§ GSF-Institut für Humangenetik, Neuherberg, Germany

1 To whom correspondence should be addressed. e-mail: wkoch{at}dhm.mhn.de

Experimental data support a protective function of apolipoprotein E (apoE) against restenosis, the main factor limiting the long-term benefit of percutaneous coronary interventions. We investigated the possibility that the single nucleotide polymorphisms (SNPs) –219G/T, 113G/C, 334T/C, and 472C/T of the gene encoding apoE (APOE) are associated with the incidence of death and myocardial infarction or restenosis after stenting in coronary arteries. In addition, we asked whether the apoE isotype-related {varepsilon}2/{varepsilon}3/{varepsilon}4 polymorphism, defined by specific allele combinations (haplotypes) of the 334T/C and 472C/T polymorphism, and other APOE haplotypes, derived from all four SNPs investigated, are associated with adverse clinical and angiographic outcomes after stenting. Our study included 1,850 consecutive patients with symptomatic coronary artery disease (CAD) who underwent stent implantation. Follow-up angiography was performed in 1,556 patients (84.1%) at 6 months after the intervention. We found that none of the APOE SNPs is associated with death and myocardial infarction or restenosis after stenting. In addition, we observed no relationship between APOE haplotypes and adverse outcomes.

In conclusion, the APOE –219G/T, 113G/C, 334T/C, and 472C/T polymorphisms, either alone or in combination, do not represent genetic markers of the risk of thrombotic and restenotic complications in patients with CAD treated with coronary stenting.

Abbreviations: apoE, apolipoprotein E; APOE, gene encoding apolipoprotein E, CAD, coronary artery disease; CI, confidence interval; SNP, single nucleotide polymorphism

Supplementary key words coronary artery disease • APOE {varepsilon} alleles • APOE haplotypes • TaqMan genotyping


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