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Journal of Lipid Research, Vol. 46, 1-10, January 2005
Copyright © 2005 by American Society for Biochemistry and Molecular Biology

Thematic Review

Thematic review series: The Immune System and Atherogenesis. Immune function in atherogenesis

Godfrey S. Getz¹

Department of Pathology, Biochemistry, and Molecular Biology, University of Chicago, Chicago, IL

¹ To whom correspondence should be addressed. e-mail: g-getz{at}uchicago.edu

In this overview to a new thematic series on the immune system and atherogenesis, I provide a very brief summary of current conceptions of atherogenesis, of the innate and adaptive immune systems, and of the participation of the latter in atherogenesis, with particular emphasis on studies of the involvement of the immune system in atherosclerosis reported in the last 2 years. This is followed by a short outline of the eight reviews that will make up this thematic series.

The overview is concluded with some caveats that should be considered in the analysis of atherosclerosis in experimental animals.

Abbreviations: apoE, apolipoprotein E; CD40L, CD40 ligand; CRP, C-reactive protein; dn, dominant negative; IL, interleukin; MHC, major histocompatibility complex; NF-B, nuclear factor B; NK, natural killer; NK-T, natural killer T; OxLDL, oxidized low density lipoprotein; RAG, recombination-activating gene; SAA, serum amyloid A; TCR, T-cell receptor; TGF, transforming growth factor; Th cell, T-helper cell; TNF, tumor necrosis factor

Supplementary key words innate immunity • adaptive immunity • cytokines

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