J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1194/jlr.M500343-JLR200 on October 28, 2005

Papers In Press, published online ahead of print January 1, 2006
J. Lipid Res., doi:10.1194/jlr.M500343-JLR200
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrow All Versions of this Article:
M500343-JLR200v1
47/1/144    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hodoglugil, U.
Right arrow Articles by Mahley, R. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hodoglugil, U.
Right arrow Articles by Mahley, R. W.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Journal of Lipid Research, Vol. 47, 144-153, January 2006
Copyright © 2006 by American Society for Biochemistry and Molecular Biology

Apolipoprotein A-V: a potential modulator of plasma triglyceride levels in Turksboxs

Ugur Hodoglugil*,{dagger}, Sinan Tanyolaç*,§, David W. Williamson*,**, Yadong Huang*,{dagger}{dagger} and Robert W. Mahley1,*,{dagger},{dagger}{dagger},§§

* Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, San Francisco, CA
{dagger} Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA
** Graduate Program in Biological and Medical Informatics, University of California, San Francisco, San Francisco, CA
{dagger}{dagger} Department of Pathology, University of California, San Francisco, San Francisco, CA
§§ Department of Medicine, University of California, San Francisco, San Francisco, CA
§ Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul University, Istanbul, Turkey

boxs The online version of this article (available at http://www.jlr.org) contains three additional tables.

Published, JLR Papers in Press, October 28, 2005.

1 To whom correspondence should be addressed. e-mail: rmahley{at}gladstone.ucsf.edu

The apolipoprotein A-V gene (APOA5) plays an important role in determining plasma triglyceride levels. We studied the effects of APOA5 polymorphisms on plasma triglyceride levels in Turks, a population with low levels of HDL cholesterol and a high prevalence of coronary artery disease. We found 15 polymorphisms, three of which were novel. Seven haplotype-tagging single nucleotide polymorphisms (SNPs) were chosen and genotyped in ~3,000 subjects. The rare alleles of the –1464T>C, –1131T>C, S19W, and 1259T>C SNPs were significantly associated with increased triglyceride levels (19–86 mg/dl; P < 0.05) and had clear gene-dose effects. Haplotype analysis of the nine common APOA5 haplotypes revealed significant effects on triglyceride levels (P < 0.001). Detailed analysis of haplotypes clearly showed that the –1464T>C polymorphism had no effect by itself but was a marker for the –1131T>C, S19W, and 1259T>C polymorphisms. The –1131T>C and 1259T>C polymorphisms were in a strong but incomplete linkage disequilibrium and appeared to have independent effects. Thus, the APOA5 –1131T>C, S19W, and 1259T>C rare alleles were associated with significant increases in plasma triglyceride levels. At least one of these alleles was present in ~40% of the Turks. Similar associations were observed for –1131T>C and S19W in white Americans living in San Francisco, California.

Supplementary key words Turkish population • polymorphism • haplotype • high density lipoprotein cholesterol

Abbreviations: APOA5, apolipoprotein A-V gene; BMI, body mass index; CAD, coronary artery disease; HDL-C, high density lipoprotein cholesterol; htSNP, haplotype-tagging single nucleotide polymorphism; LD, linkage disequilibrium; SNP, single nucleotide polymorphism; THS, Turkish Heart Study; UTR, untranslated region


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Lipid Res.Home page
E. Olano-Martin, E. C. Abraham, R. Gill-Garrison, A. M. Valdes, K. Grimaldi, F. Tang, K. G. Jackson, C. M. Williams, and A. M. Minihane
Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender
J. Lipid Res., May 1, 2008; 49(5): 945 - 953.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
R. Elosua, J. M. Ordovas, L. A. Cupples, C.-Q. Lai, S. Demissie, C. S. Fox, J. F. Polak, P. A. Wolf, R. B. D'Agostino Sr., and C. J. O'Donnell
Variants at the APOA5 locus, association with carotid atherosclerosis, and modification by obesity: the Framingham Study
J. Lipid Res., May 1, 2006; 47(5): 990 - 996.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2006 by the American Society for Biochemistry and Molecular Biology.