HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: M600288-JLR200v1 47/11/2475    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Anuurad, E. Articles by Berglund, L. Search for Related Content PubMed PubMed Citation Articles by Anuurad, E. Articles by Berglund, L. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 47, 2475-2481, November 2006
Copyright © 2006 by American Society for Biochemistry and Molecular Biology

Protective effect of apolipoprotein E2 on coronary artery disease in African Americans is mediated through lipoprotein cholesterol

Erdembileg Anuurad^*, Jill Rubin, Guijing Lu^*, Thomas A. Pearson, Steve Holleran^**, Rajasekhar Ramakrishnan^** and Lars Berglund^1,*,

^* Department of Medicine, University of California, Davis, CA
Department of Medicine, Columbia University, New York, NY
Department of Family and Community Medicine, University of Rochester, Rochester, NY
^** Department of Pediatrics, Columbia University, New York, NY
Department of Veterans Affairs Northern California Health Care System, Davis, CA

Published, JLR Papers in Press, August 3, 2006.

¹ To whom correspondence should be addressed. e-mail: lars.berglund{at}ucdmc.ucdavis.edu

We studied the relationship of apolipoprotein E (apoE) isoforms and coronary artery disease (CAD) in 224 African Americans and 326 Caucasians undergoing diagnostic coronary angiography. The presence of CAD was defined as >50% stenosis in at least one artery. ApoE allele frequencies were 0.12, 0.62, and 0.26 for 2, 3, and 4, respectively, in African Americans and 0.08, 0.78, and 0.14 for 2, 3, and 4, respectively, in Caucasians. Among African Americans, CAD was present in 9 of 34 2 carriers (26%), significantly smaller (P < 0.05) in proportion compared with 39 of 82 3 carriers and 43 of 92 4 carriers (48% and 47%, respectively), suggesting a protective effect of the 2 allele. No such difference was seen in Caucasians. In African Americans but not Caucasians, LDL cholesterol was lower in 2 carriers than in 3 and 4 carriers (106 vs. 127 and 134 mg/dl, respectively; P < 0.005). After adjusting for lipid levels, the association between apoE2 and CAD was no longer significant. Thus, the protective effect of apoE2 seen in African Americans could be explained by a favorable lipid profile in 2 carriers, whereas in Caucasians, the absence of such a protective effect could be attributable to the lack of effect of apoE2 on the lipid profile.

Supplementary key words coronary heart disease • polymorphism • cardiovascular risk factors • genetics

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				E. Anuurad, J. Rubin, A. Chiem, R. P. Tracy, T. A. Pearson, and L. Berglund High Levels of Inflammatory Biomarkers Are Associated with Increased Allele-Specific Apolipoprotein(a) Levels in African-Americans J. Clin. Endocrinol. Metab., April 1, 2008; 93(4): 1482 - 1488. [Abstract] [Full Text] [PDF]

				E. Anuurad, G. Lu, J. Rubin, T. A. Pearson, and L. Berglund ApoE genotype affects allele-specific apo[a] levels for large apo[a] sizes in African Americans: the Harlem-Basset Study J. Lipid Res., March 1, 2007; 48(3): 693 - 698. [Abstract] [Full Text] [PDF]