J. Lipid Res.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1194/jlr.M500420-JLR200 on February 7, 2006

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
M500420-JLR200v1
47/5/921    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kim, H. H.
Right arrow Articles by Chung, J. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kim, H. H.
Right arrow Articles by Chung, J. H.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Journal of Lipid Research, Vol. 47, 921-930, May 2006
Copyright © 2006 by American Society for Biochemistry and Molecular Biology

Photoprotective and anti-skin-aging effects of eicosapentaenoic acid in human skin in vivo

Hyeon Ho Kim*, Soyun Cho{dagger}, Serah Lee*, Kyu Han Kim*, Kwang Hyun Cho*, Hee Chul Eun* and Jin Ho Chung1,*

* Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging Research, Clinical Research Institutes, Seoul National University Hospital, and Institute of Dermatological Science, Seoul National University, Seoul, Korea
{dagger} Department of Dermatology, Seoul National University Boramae Hospital, Seoul, Korea

Published, JLR Papers in Press, February 7, 2006.

1 To whom correspondence should be addressed. e-mail: jhchung{at}snu.ac.kr

Skin aging can be attributed to photoaging (extrinsic) and chronological (intrinsic) aging. Photoaging and intrinsic aging are induced by damage to human skin attributable to repeated exposure to ultraviolet (UV) irradiation and to the passage of time, respectively. In our previous report, eicosapentaenoic acid (EPA) was found to inhibit UV-induced matrix metalloproteinase-1 (MMP-1) expression in human dermal fibroblasts. Therefore, we investigated the effects of EPA on UV-induced skin damage and intrinsic aging by applying EPA topically to young and aged human skin, respectively. By immunohistochemical analysis and Western blotting, we found that topical application of EPA reduced UV-induced epidermal thickening and inhibited collagen decrease induced by UV light. It was also found that EPA attenuated UV-induced MMP-1 and MMP-9 expression by inhibiting UV-induced c-Jun phosphorylation, which is closely related to UV-induced activator protein-1 activation, and by inhibiting JNK and p38 activation. EPA also inhibited UV-induced cyclooxygenase-2 (COX-2) expression without altering COX-1 expression. Moreover, it was found that EPA increased collagen and elastic fibers (tropoelastin and fibrillin-1) expression by increasing transformin growth factor-ß expression in aged human skin. Together, these results demonstrate that topical EPA has potential as an anti-skin-aging agent.

Supplementary key words polyunsaturated fatty acid • intrinsic aging • photoaging • ultraviolet irradiation

Abbreviations: AA, arachidonic acid; AP-1, activator protein-1; COX-2, cyclooxygenase-2; DHA, docosahexaenoic acid; ECM, extracellular matrix; EPA, eicosapentaenoic acid; MAPK, mitogen-activated protein kinase; MED, minimal erythma dose; MMP, matrix metalloproteinase; PG, prostaglandin; TGF-ß, transforming growth factor-ß; UV, ultraviolet


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Mol. Endocrinol.Home page
K. C. N. Chang, Q. Shen, I. G. Oh, S. A. Jelinsky, S. F. Jenkins, W. Wang, Y. Wang, M. LaCava, M. R. Yudt, C. C. Thompson, et al.
Liver X Receptor Is a Therapeutic Target for Photoaging and Chronological Skin Aging
Mol. Endocrinol., November 1, 2008; 22(11): 2407 - 2419.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
M. C Cosgrove, O. H Franco, S. P Granger, P. G Murray, and A. E Mayes
Dietary nutrient intakes and skin-aging appearance among middle-aged American women
Am. J. Clinical Nutrition, October 1, 2007; 86(4): 1225 - 1231.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2006 by the American Society for Biochemistry and Molecular Biology.