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Papers In Press, published online ahead of print March 1, 2007
J. Lipid Res., doi:10.1194/jlr.M600431-JLR200

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Journal of Lipid Research, Vol. 48, 693-698, March 2007
Copyright © 2007 by American Society for Biochemistry and Molecular Biology

ApoE genotype affects allele-specific apo[a] levels for large apo[a] sizes in African Americans: the Harlem-Basset Study

Erdembileg Anuurad^*, Guijing Lu^*, Jill Rubin, Thomas A. Pearson and Lars Berglund^1,*,**

^* Department of Medicine, University of California, Davis, CA
Department of Medicine, Columbia University, New York, NY
Department of Family and Community Medicine, University of Rochester, Rochester, NY
^** Department of Veterans Affairs Northern California Health Care System, Sacramento, CA

The online version of this article (available at http://www.jlr.org) contains additional two figures and one table.

Published, JLR Papers in Press, December 15, 2006.

¹ To whom correspondence should be addressed. e-mail: lars.berglund{at}ucdmc.ucdavis.edu

The genetic variability of apolipoprotein E (apoE) influences plasma lipoprotein levels, and allele frequencies differ between African Americans and Caucasians. As African Americans have higher lipoprotein [a] (Lp[a]) levels than Caucasians, we investigated the effects of the apoE gene on allele-specific apolipoprotein [a] (apo[a]) levels across ethnicity. We determined apo[a] sizes, allele-specific apo[a] levels (i.e., levels associated with alleles defined by size), and the apoE gene polymorphism in 231 African Americans and 336 Caucasians. African Americans, but not Caucasians, with the apo E2 genotype had lower levels of Lp[a] compared with those with the apo E4 genotype (9.6 vs. 11.2 nmol/l; P = 0.034, expressed as square root levels). Distribution of apo[a] alleles across apoE genotypes were similar between African Americans and Caucasians. Among African Americans with large apo[a], the allele-specific apo[a] level was significantly lower among 2 carriers compared with 3 or 4 carriers (5.4 vs. 6.6 and 7.4 nmol/l, respectively; P < 0.005, expressed as square root levels). In contrast, there was no significant difference in allele-specific apo[a] levels across apoE genotypes among Caucasians. For large apo[a] sizes, apoE genotype contributed to the observed African American-Caucasian differences in allele-specific apo[a] levels.

Supplementary key words lipoprotein [a] • polymorphisms • apolipoprotein E • genetics • ethnicity • apolipoprotein [a]

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