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Originally published In Press as doi:10.1194/jlr.M700399-JLR200 on November 6, 2007

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Journal of Lipid Research, Vol. 49, 369-375, February 2008
Copyright © 2008 by American Society for Biochemistry and Molecular Biology

Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population

Na-Ping Tang1,*, Lian-Sheng Wang1,{dagger}, Li Yang1,§, Bo Zhou1,*, Hai-Juan Gu*, Qing-Min Sun*, Ri-Hong Cong*, Huai-Jun Zhu* and Bin Wang2,*

* Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing, China
{dagger} Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
§ Department of General Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, China

Published, JLR Papers in Press, November 6, 2007.

1 N-P. Tang, L-S. Wang, L. Yang, and B. Zhou contributed equally to this work.

2 To whom correspondence should be addressed. e-mail: binwang{at}njmu.edu.cn

The aim of the present study was to assess the influence of the endothelial lipase (EL) gene 584C/T variant, which results in a change at codon 111 of the EL gene from threonine to isoleucine, on the risk of coronary artery disease (CAD) in a Chinese population. The study population consisted of 265 CAD patients and 265 age- and sex-matched control subjects. The T allele frequency was significantly lower among CAD patients than among control subjects (18.3% vs. 29.8%; P < 0.001). In both the CAD and control groups, the T allele carriers had higher high density lipoprotein cholesterol (HDL-C) levels than homozygote C allele carriers. In a multiple logistic regression model adjusted for age, sex, body mass index, smoking, hypertension, diabetes, hyperlipidemia, and low density lipoprotein cholesterol, a significantly decreased risk of developing CAD was found in subjects carrying a variant CT or TT genotype (odds ratio = 0.496, 95% confidence interval = 0.341–0.723; P < 0.001), and the significance persisted after further adjustment for HDL-C. In conclusion, our observation that the EL 584T allele was associated with protection from CAD in this Chinese population replicates the findings in a Japanese study, which found a similar association of this allele with acute myocardial infarction, independent of HDL-C levels.

Supplementary key words genetic variant • polymorphism • high density lipoprotein cholesterol

Abbreviations: AMI, acute myocardial infarction; BMI, body mass index; CAD, coronary artery disease; CI, confidence interval; EL, endothelial lipase; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; OR, odds ratio; TC, total cholesterol; TG, triglyceride


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