J. Lipid Res. Please sign the JLR Guestbook
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1194/jlr.R800001-JLR200 on January 8, 2008

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
R800001-JLR200v1
49/3/499    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schmuth, M.
Right arrow Articles by Feingold, K. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schmuth, M.
Right arrow Articles by Feingold, K. R.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Journal of Lipid Research, Vol. 49, 499-509, March 2008
Copyright © 2008 by American Society for Biochemistry and Molecular Biology

Thematic Review

Thematic Review Series: Skin Lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology

Matthias Schmuth1,*,{dagger},§, Yan J. Jiang**,{dagger}{dagger}, Sandrine Dubrac§, Peter M. Elias*,{dagger} and Kenneth R. Feingold*,**,{dagger}{dagger}

* Department of Dermatology, University of California, San Francisco, CA
{dagger} Department of Medicine, University of California, San Francisco, CA
§ Dermatology Section, Department of Veterans Affairs Medical Center, San Francisco, CA
** Metabolism Section, Department of Veterans Affairs Medical Center, San Francisco, CA
{dagger}{dagger} Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria

Published, JLR Papers in Press, January 8, 2008.

1 To whom correspondence should be addressed. e-mail: schmuthm{at}derm.ucsf.edu

The epidermis is a very active site of lipid metabolism, and all peroxisome proliferator-activated receptor (PPAR) and liver X receptor (LXR) isoforms are expressed in the epidermis. Activation of PPAR{alpha}, -β/{delta}, or -{gamma} or LXRs stimulates keratinocyte differentiation. Additionally, activation of these receptors also improves permeability barrier homeostasis by a number of mechanisms, including stimulating epidermal lipid synthesis, increasing lamellar body formation and secretion, and increasing the activity of enzymes required for the extracellular processing of lipids in the stratum corneum, leading to the formation of lamellar membranes that mediate permeability barrier function. The stimulation of keratinocyte differentiation and permeability barrier formation also occurs during fetal development, resulting in accelerated epidermal development. PPAR and LXR activation regulates keratinocyte proliferation and apoptosis, and studies have shown that these receptors play a role in cutaneous carcinogenesis. Lastly, PPAR and LXR activation is anti-inflammatory, reducing inflammation in animal models of allergic and irritant contact dermatitis. Because of their broad profile of beneficial effects on skin homeostasis, PPAR and LXR have great potential to serve as drug targets for common skin diseases such as psoriasis, atopic dermatitis, and skin cancer.

Supplementary key words cancer • cutaneous • differentiation • inflammation • permeability barrier • proliferation • transcription factor • skin • stratum corneum

Abbreviations: IL-1{alpha}, interleukin-1{alpha}; LXR, liver X receptor; NF-{kappa}B, nuclear factor-{kappa}B; PPAR, peroxisome proliferator-activated receptor; RXR, retinoid X receptor; SULT2B1b, sulfotransferase type 2B isoform 1b; TNF-{alpha}, tumor necrosis factor-{alpha}; TPA, 12-O-tetradecanoyl-phorbol-13-acetate; TUNEL, terminal uridine deoxynucleotidyl transferase


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2008 by the American Society for Biochemistry and Molecular Biology.