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Originally published In Press as doi:10.1194/jlr.M800102-JLR200 on April 17, 2008

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Journal of Lipid Research, Vol. 49, 1746-1751, August 2008
Copyright © 2008 by American Society for Biochemistry and Molecular Biology

Plasma fatty acid binding protein 4 is associated with atherogenic dyslipidemia in diabetes

Anna Cabré, Iolanda Lázaro, Josefa Girona, Josep Maria Manzanares, Francesc Marimón, Núria Plana, Mercedes Heras and Lluís Masana1

Research Unit on Lipids and Atherosclerosis, CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Faculty of Medicine and Health Sciences, Department of Internal Medicine, Saint Joan University Hospital, Reus, Spain

This work was supported by grants from the Fondo de Investigación Sanitaria (FIS 01/0398, FIS PI02/1051, FIS PI05/1954, and CIBERDEM), Madrid, Spain. I.L. is a recipient of a predoctoral fellowship from the DURSI of the Generalitat de Catalunya and the European Social Funding (2005FIC 00303).

Published, JLR Papers in Press, April 17, 2008.

1 To whom correspondence should be addressed. e-mail: luis.masana{at}urv.cat

The aim of this study was to evaluate the impact of adipocyte fatty acid binding protein 4 (FABP4) on the lipid profile in type 2 diabetic subjects. Plasma levels of FABP4 and adiponectin and an extensive lipid profile were analyzed in 169 type 2 diabetic subjects and 105 controls. Type 2 diabetic subjects were categorized according the presence of atherogenic dyslipidemia. Univariate statistical analyses, partial correlation tests, and binary logistic regression models were applied. In type 2 diabetic subjects, FABP4 was positively correlated with plasma triglycerides (P = 0.007), apolipoprotein C-III (apoC-III) (P = 0.009), and all the components of triglyceride-rich lipoproteins, including VLDL triglycerides (P = 0.002), VLDL-cholesterol (P = 0.001), and VLDL apoB (P = 0.001). FABP4 was inversely correlated with apoA-I (P = 0.038), HDL-cholesterol (P = 0.002), and HDL apoA-I (P = 0.010) in type 2 diabetic subjects. These correlations are not significantly affected by age, gender, body mass index, adiponectin, insulin, or any pharmacological treatment. The associations are even stronger when the FABP4/adiponectin ratio is considered. None of these associations were observed in controls. High FABP4 and low adiponectin levels are independent predictors of atherogenic dyslipidemia. In conclusion, FABP4 plasma concentrations hold strong potential for development as a clinical biomarker for atherogenic dyslipidemia, independent of obesity and insulin resistance, in type 2 diabetic subjects.

Supplementary key words insulin • lipids • type 2 diabetes


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