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J. Lipid Res.
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A more recent version of this article appeared on March 1, 2003

Papers In Press, published online ahead of print January 16, 2003
J. Lipid Res., doi:10.1194/jlr.C200019-JLR200
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Submitted on November 22, 2002
Revised on December 23, 2002
Accepted on January 3, 2003

CONVERSION OF HEXADECANOIC ACID (PALMITIC ACID, C16:0) TO HEXADECENOIC ACID (C16:1 n-10) BY RAT D6-DESATURASE

Hervé Guillou, Vincent ;Rioux, Daniel Catheline, Jean-Noël Thibault, Monique Bouriel, Sophie Jan, Sabine D'Andrea, and Philippe Legrand

Biochemistry, ENSAR-INRA, Rennes 35042

Corresponding Author: Philippe.Legrand{at}agrorennes.educagri.fr

A higher content of C16:1 n-10 has recently been reported in the preputial gland of mice with a targeted disruption of the gene encoding Stearoyl-CoA Desaturase 1 (SCD1 -/- mice) when compared to wild-type mice. This result has provided the first physiological evidence for the presence and regulation of a palmitoyl-CoA D6-desaturase in mammals. To investigate the putative involvement of the known D6-desaturase (FADS2) in this process, COS-7 cells expressing rat D6-desaturase were incubated with C16:0. Transfected cells were able to synthesize C16:1 n-10, while non-transfected cells did not produce any C16:1 n-10. Evidence is therefore presented that the rat D6-desaturase, which acts on the 18- and 24-carbon fatty acids of the n-6 and n-3 series, is also able to catalyze palmitic acid D6-desaturation.


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