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A more recent version of this article appeared on February 1, 2005

Papers In Press, published online ahead of print November 16, 2004
J. Lipid Res., doi:10.1194/jlr.C400011-JLR200
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Submitted on August 6, 2004
Revised on October 18, 2004
Accepted on November 2, 2004

Serum sphingomyelin levels are related to the clearance of postprandial remnant-like particles

Axel Schlitt, Mohammed R. Hojjati, Hans von Gizycki, Karl J. Lackner, Stefan Blankenberg, Bernhard Schwaab, Juergen Meyer, Hans J. Rupprecht, and Xian-Cheng Jiang

Department of Anatomy and Cell Biology, SUNY, Brooklyn, NY 11203

Corresponding Author: xjiang{at}downstate.edu

It is known that sphingomyelin (SM) content is higher in apoB-containing particles (BLp) than in high-density lipoprotein, and that BLp levels, including chylomicrons and their remnant particles, are positively related to atherosclerosis. To evaluate the relationship between serum SM and postprandial remnant particle levels, we determined SM, triglyceride (TG), and cholesterol levels in serum and in remnant-like particles (RLP) before and 3, 5, 7, and 10 hours after a high-fat meal, in 31 healthy subjects. We found that serum SM, like serum TG, was increased to its maximum 3 hours after fat loading, and then gradually decreased to basal levels after 10 hours. More important, we determined that SM and TG levels in RLP were parallel. Serum SM was positively correlated with serum TG (p<0.001), RLP SM (p<0.001), RLP TG (p<0.001), and RLP cholesterol levels (p<0.001), respectively. It is our conclusion that serum SM is a marker for the clearance of RLP.


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