J. Lipid Res.
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A more recent version of this article appeared on June 1, 2005

Papers In Press, published online ahead of print April 1, 2005
J. Lipid Res., doi:10.1194/jlr.C500003-JLR200
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Submitted on January 20, 2005
Revised on March 14, 2005
Accepted on March 23, 2005

Increased arachidonic acid concentration in the brain of Flinders Sensitive Line rats, an animal model of depression

Pnina Green, Iris Gispan-Herman, and Gal Yadid

Department of Internal Medicine, Tel Aviv University, Petah Tiqva 49100

Corresponding Author: pgreen{at}post.tau.ac.il; pgreen@clalit.org.il

Depression may be associated with impaired membrane polyunsaturated fatty acid (PUFA) composition, especially decreased n-3 PUFA. This assumption has not been tested at the level of brain tissue. Moreover, most studies were confounded by dietary variability. We examined the fatty acid (FA) composition of selected brain areas in an animal model of depression, the Flinders Sensitive Line (FSL) rat, and compared the findings to controls fed identical diets. In all brain regions studied, the concentration of arachidonic acid was significantly higher in the FSL rats: in the hypothalamus by 21%; in the nucleus accumbens by 24%; in the prefrontal cortex by 31%; and in the striatum by 23%. No significant differences were observed for n-3 PUFA, or for the saturated and the monounsaturated FAs. Our results confirm the existence of altered brain PUFA composition in an animal model of depression. The finding of increased arachidonic acid, an n-6 PUFA, rather than decreased n-3 PUFA, emphasizes the importance of both PUFA families in the pathophysiologic processes underlying depression. The FSL rat is a useful tool for further elucidation of the FA disturbances in depression.


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I. Kan, E. Melamed, D. Offen, and P. Green
Docosahexaenoic acid and arachidonic acid are fundamental supplements for the induction of neuronal differentiation
J. Lipid Res., March 1, 2007; 48(3): 513 - 517.
[Abstract] [Full Text] [PDF]


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