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A more recent version of this article appeared on July 1, 2007

Papers In Press, published online ahead of print April 19, 2007
J. Lipid Res., doi:10.1194/jlr.C700008-JLR200
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Submitted on March 2, 2007
Revised on April 19, 2007
Accepted on April 19, 2007

Identification and quantification of dolichol and dolichoic acid in neuromelanin from substantia nigra of the human brain

Weslyn C. Ward, Ziqiang Guan, Fabio A. Zucca, Ruggero G. Fariello, Reza Kordestani, Luigi Zecca, Christian R. H. Raetz, and John D. Simon

Chemistry, Duke University, Durham, NC 27708

Corresponding Author: jsimon{at}duke.edu

Neuromelanin (NM) isolated from the substantia nigra of the human brain is found to contain a series of dolichoic acids (dol-CA) containing 14-20 isoprene units. This is the first observation of dol-CA in a natural system. Using internally spiked nor-dolichol and nor-dolichoic acid standards, the concentrations of dolichol (dol) and dol-CA present in NM were determined. Remarkably, dol was only four times as abundant as dol-CA in NM. The distribution of dol-CA chains lengths in NM also differed from that of dol, suggesting that the enzyme(s) responsible for the conversion of dol to dol-CA prefer a dolichol substrate containing 19 isoprene units.


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