Submitted on February 8, 2008
Revised on May 27, 2008
Accepted on May 28, 2008
Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla
Jimin Ren, Ivan Dimitrov, A. Dean Sherry, and Craig R. Malloy
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390
Corresponding Author: Craig.Malloy{at}UTSouthwestern.edu
1H NMR spectroscopy at 7T was evaluated as a new method to quantify fat composition noninvasively. In validation experiments, the composition of a known mixture of triolein, tristearin and trilinolein agreed well with estimates by 1H NMR spectroscopy. Triglycerides in calf subcutaneous tissue and in tibial bone marrow were examined in ten healthy subjects by 1H spectroscopy and chemical shift imaging. Ten well-resolved proton resonances from triglycerides were detected, and T1 and T2 were measured. After correction for differential relaxation effects, the composition of marrow and adipose fat was 27 ± 9% saturated, 48 ± 8% monounsaturated, and 25 ± 10% diunsaturated. Triglyceride composition was not different between marrow and subcutaneous adipose tissue. Proton spectroscopy at 7T offers a simple noninvasive and painless method to obtain detailed information about lipid composition in humans.
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