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A more recent version of this article appeared on May 1, 2005

Papers In Press, published online ahead of print February 16, 2005
J. Lipid Res., doi:10.1194/jlr.E400004-JLR200
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Submitted on December 22, 2004
Revised on February 4, 2005
Accepted on February 4, 2005

A comprehensive classification system for lipids

Eoin Fahy, Shankar Subramaniam, H. Alex Brown, Christopher K. Glass, Alfred H. Merrill Jr., Robert C. Murphy, Christian R.H. Raetz, David W. Russell, Yousuke Seyama, Walter Shaw, Takao Shimizu, Frederich Spener, Gerrit van Meer, Michael S. VanNieuwenhze, Stephen H. White, Joseph Witztum, and Edward A. Dennis

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92037-0601

Corresponding Author: edennis{at}ucsd.edu

Lipids are produced, transported and recognized by the concerted actions of numerous enzymes, binding proteins and receptors. A comprehensive analysis of lipid molecules, “lipidomics”, in the context of genomics and proteomics is crucial to understanding cellular physiology and pathology and consequently, lipid biology has become a major research target of the postgenomic revolution and systems biology. To facilitate international communication about lipids, a comprehensive classification of lipids with a common platform that is compatible with informatics requirements has been developed to deal with the massive amounts of data that will be generated by our lipid community. As an initial step in this development, we divide lipids into eight categories [Fatty Acyls, Glycerolipids, Glycerophospholipids, Sphingolipids, Sterol Lipids, Prenol Lipids, Saccharolipids, and Polyketides] containing distinct classes and subclasses of molecules, devise a common manner of representing the chemical structures of individual lipids and their derivatives,and provide a 12-digit identifier for each unique lipid molecule. . The lipid classification scheme is chemically based and driven by the distinct hydrophobic and hydrophilic elements that compose the lipid. This structured vocabulary will facilitate the systematization of lipid biology and enable the cataloging of lipids and their properties in a way that is compatible with other macromolecular databases.


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