J. Lipid Res.
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A more recent version of this article appeared on September 1, 2005

Papers In Press, published online ahead of print July 1, 2005
J. Lipid Res., doi:10.1194/jlr.E500003-JLR200
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Submitted on June 3, 2005
Revised on June 20, 2005
Accepted on July 1, 2005

A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases

Mary C. Hunt, Junji Yamada, Lois J. Maltais, Matthew Wright, Ernesto J. Podesta, and Stefan E. H. Alexson

Department of Laboratory Medicine, Karolinska Institutet, Stockholm SE 141 86

Corresponding Author: mary.hunt{at}labmed.ki.se

Acyl-CoA thioesterases, also known as acyl-CoA hydrolases, are a group of enzymes that hydrolyze CoA esters such as acyl-CoAs (saturated, unsaturated, branched chain), bile acid-CoAs, CoA esters of prostaglandins etc, to the corresponding free acid and coenzyme A. There is however significant confusion regarding the nomenclature of these genes. In agreement with the HUGO Gene Nomenclature Committee (HGNC) and the Mouse Genomic Nomenclature Committee (MGNC), a revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases has been suggested for the 12 member family. The family root symbol is ACOT, with human genes named ACOT1-12, and rat and mouse named Acot1-12. Several of the ACOT genes are the result of splicing events and these splice variants are catalogued.


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