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Papers In Press, published online ahead of print October 1, 2002
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Submitted on February 7, 2002
Div. Metabolic Disease and Nutrition, Dr. von Hauner Childres's Hospital Ludwig-Maximilians Univ. of Munich, Munchen D-80337
Corresponding Author: berthold.koletzko{at}kk-i.med.uni-muenchen.de
2 Abstract: Placental fatty acid transfer in humans in vivo was studied using stable isotopes. Four pregnant women undergoing cesarean section received four hours before delivery an oral dose of 13 C-palmitic acid (PA), 13 C-oleic acid (OA), 13 C-linoleic acid (LA) and 13 C-docosahexaenoic acid (DHA). Maternal blood samples were collected at -4 (basal), -3, -2, -1, 0 and +1 hour relative to time of cesarean section. At the time of birth, venous cord blood and placental tissue were collected. Fatty acid composition was determined by gas-liquid chromatography and isotopic enrichment by gas chromatography-combustion-isotope ratio mass spectrometry. 13 C-enrichment of fatty acids in the non esterified fatty acids (NEFA) of cord plasma tended to be higher than in NEFA of placenta with statistically significant differences for the non esterified OA and DHA ( 13 C-PA: 0.024±0.011 vs. 0.001±0.001; 13 C-OA: 0.042±0.008 vs. 0.005±0.003; 13 C-LA: 0.038±0.010 vs. 0.008±0.002; 13 C-DHA: 0.059±0.009 vs. 0.010±0.003). The ratio of tracer fatty acid concentrations of placenta to maternal plasma was significantly higher for 13 C-DHA than for the other fatty acids ( 13 C-PA: 7.1±1%; 13 C-OA: 3.8±0.4%; 13 C-LA: 9.2±1.3%; 13 C-DHA: 25.9±3.4%). These results suggest that only a part of the placental NEFA participated in fatty acid transfer and that the placenta showed a preferential accretion of DHA relative to the other fatty acids. Key words: fatty acids, long chain polyunsaturated fatty acids, placenta, pregnancy, stable isotopes
Revised on July 17, 2002
Accepted on September 19, 2002
In vivo investigation of the placental transfer of 13 C-labeled fatty acids in humans
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