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A more recent version of this article appeared on January 1, 2003

Papers In Press, published online ahead of print November 4, 2002
J. Lipid Res., doi:10.1194/jlr.M200319-JLR200
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Submitted on August 12, 2002
Revised on October 17, 2002
Accepted on October 18, 2002

Efficiency of intestinal cholesterol absorption in humans is not related to apolipoprotein E phenotype

Klaus von Bergmann, Dieter Lütjohann, Bernhard Lindenthal, and Armin Steinmetz

Department of Clinical Pharmacology, University of Bonn, Bonn 53105

Corresponding Author: vonbergmann{at}uni-bonn.de

The present study investigated the role of apolipoprotein E phenotype on intestinal cholesterol absorption and cholesterol synthesis. Studies were carried out in eight subjects homozygous for the apolipoprotein E4 and twelve subjects homozygous for the E2 allele (six normocholesterolemic volunteers and six patients with type III hyperlipoproteinemia). Cholesterol absorption did not differ between the three groups of subjects and averaged 38 „b 2% (Mean „b SEM) in normolipemic E2/2, 37 „b 4% in type III hyperlipemic E2/2, and 41 „b 3% in E4/4 subjects, respectively. Dietary intake of fat and cholesterol had no influence on cholesterol absorption efficiency. A positive correlation between efficiency of cholesterol absorption and the ratio of campesterol to cholesterol in plasma, an indirect marker for cholesterol absorption, was observed after combining the results of the three groups (r = 0.504; p < 0.02). Bile acid and total cholesterol synthesis were also not affected by the different apolipoprotein E alleles, but the well-known relationship between body weight and cholesterol synthesis was noticed (r = 0.574; p < 0.01). Thus, the present study provides evidence that the efficiency of intestinal absorption and synthesis of cholesterol in humans are not related to the apolipoprotein E phenotype.


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