| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
Papers In Press, published online ahead of print November 4, 2002
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on August 29, 2002
Departmente de Biochimie, CNRS, UMR 6543, Nice 06108
Corresponding Author: ailhaud{at}unice.fr
The increasing prevalence of childhood obesity results from a combination of environmental factors. Among them, high-fat intake is associated with fat mass gain through fatty acid activation of peroxisome proliferator-activated receptors delta and gamma which promote adipogenesis. We now show that, compared to a combination of specific agonists to both receptors or to saturated, monounsaturated and omega-3 polyunsaturated fatty acids. (eicosapentaenoic and docosahexaenoic acids), arachidonic acid (C20:4, omega-6) is substantially more adipogenic in promoting the differentiation of clonal preadipocytes. This effect takes place at an early stage in the process, is blocked by cyclooxygenase inhibitors and is mimicked by carbacyclin, suggesting a role for the prostacyclin receptor (IP-R) and activation of the cyclic AMP-dependent pathways which are known to regulate the expression of the CCAAT enhancer binding proteins beta and delta implicated in adipogenesis. In vivo, during the pregnancy-lactation period, mother mice were fed either a high-fat diet rich in linoleic acid, a precursor of arachidonic acid (LO diet) or the same isocaloric diet also enriched in linoleic acid and alpha-linolenic acid, a precursor of eicosapentaenoic and docosahexaenoic acids (LO/LL diet). Body weight from weaning onwards, fat mass, epididymal fat pad weight and adipocyte size at 8 weeks of age were higher with LO diet than with LO/LL diet. In contrast, prostacyclin receptor-deficient mice fed LO diet or LO/LL diet were similar in this respect, indicating that the prostacyclin receptor is crucial in adipose tissue development. As polyunsaturated fatty acids are not equipotent in enhancing fat mass, this raises the issue of the high content of linoleic acid of the lipids ingested by women during pregnancy and lactation. It raises also the issue of its large supplementation in formula milk and infant foods, and the possible relationship with the epidemic of childhood obesity.
Revised on October 28, 2002
Accepted on November 1, 2002
Arachidonic acid and prostacyclin signaling promote adipose tissue development: A human health concern
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  I. B. Helland, L. Smith, B. Blomen, K. Saarem, O. D. Saugstad, and C. A. Drevon Effect of Supplementing Pregnant and Lactating Mothers With n-3 Very-Long-Chain Fatty Acids on Children's IQ and Body Mass Index at 7 Years of Age Pediatrics, August 1, 2008; 122(2): e472 - e479. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Madsen, L. M. Pedersen, B. Liaset, T. Ma, R. K. Petersen, S. van den Berg, J. Pan, K. Muller-Decker, E. D. Dulsner, R. Kleemann, et al. cAMP-dependent Signaling Regulates the Adipogenic Effect of n-6 Polyunsaturated Fatty Acids J. Biol. Chem., March 14, 2008; 283(11): 7196 - 7205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Grant, G. Ortiz-Colon, M. E. Doumit, and D. D. Buskirk Optimization of in vitro conditions for bovine subcutaneous and intramuscular preadipocyte differentiation J Anim Sci, January 1, 2008; 86(1): 73 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Aprikian, D. Reynaud, C. Pace-Asciak, P. Leone, F. Blancher, I. Monnard, C. Darimont, and K. Mace Neonatal dietary supplementation of arachidonic acid increases prostaglandin levels in adipose tissue but does not promote fat mass development in guinea pigs Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R2006 - R2012. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-E. Zaragosi, G. Ailhaud, and C. Dani Autocrine Fibroblast Growth Factor 2 Signaling Is Critical for Self-Renewal of Human Multipotent Adipose-Derived Stem Cells Stem Cells, November 1, 2006; 24(11): 2412 - 2419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Jacobson, H. Mundra, and S. M. Innis Intestinal responsiveness to experimental colitis in young rats is altered by maternal diet Am J Physiol Gastrointest Liver Physiol, July 1, 2005; 289(1): G13 - G20. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-M. Rodriguez, D. Pisani, C. A. Dechesne, C. Turc-Carel, J.-Y. Kurzenne, B. Wdziekonski, A. Villageois, C. Bagnis, J.-P. Breittmayer, H. Groux, et al. Transplantation of a multipotent cell population from human adipose tissue induces dystrophin expression in the immunocompetent mdx mouse J. Exp. Med., May 2, 2005; 201(9): 1397 - 1405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Bezy, C. Elabd, O. Cochet, R. K. Petersen, K. Kristiansen, C. Dani, G. Ailhaud, and E.-Z. Amri Delta-interacting Protein A, a New Inhibitory Partner of CCAAT/Enhancer-binding Protein {beta}, Implicated in Adipocyte Differentiation J. Biol. Chem., March 25, 2005; 280(12): 11432 - 11438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Baylin and H. Campos Arachidonic Acid in Adipose Tissue Is Associated with Nonfatal Acute Myocardial Infarction in the Central Valley of Costa Rica J. Nutr., November 1, 2004; 134(11): 3095 - 3099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. K. Petersen, C. Jorgensen, A. C. Rustan, L. Froyland, K. Muller-Decker, G. Furstenberger, R. K. Berge, K. Kristiansen, and L. Madsen Arachidonic acid-dependent inhibition of adipocyte differentiation requires PKA activity and is associated with sustained expression of cyclooxygenases J. Lipid Res., December 1, 2003; 44(12): 2320 - 2330. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
