J. Lipid Res.
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A more recent version of this article appeared on March 1, 2003

Papers In Press, published online ahead of print January 1, 2003
J. Lipid Res., doi:10.1194/jlr.M200398-JLR200
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Submitted on October 8, 2002
Revised on December 18, 2002
Accepted on December 18, 2002

Red blood cell fatty acid ethylesters: A significant component of fatty acid ethylesters in the blood

Catherine A. Best, Joanne E. Cluette-Brown, Miho Teruya, Ami Teruya, and Michael Laposata

Pathology Dept., Massachusetts General Hospital, Boston, MA 02114

Corresponding Author: mlaposata{at}partners.org

Although alcohol abuse is known to cause an array of ethanol induced red blood cell (RBC) abnormalities, the underlying molecular mechanisms remain poorly understood. Fatty acid ethyl esters (FAEE) are toxic nonoxidative ethanol metabolites that have been found in blood, plasma and tissues. Because FAEE have been shown to be incorporated in to phospholipid bilayers, we conducted a controlled ethanol intake study to test the hypothesis that FAEE accumulate and persist within RBC following ethanol ingestion. We demonstrated that RBC FAEE account for approximately 5 - 20 % of total whole blood FAEE, and that the fatty acid composition of FAEE in RBC and plasma are different and vary differently over time. These data indicate that a significant percentage of FAEE in the blood is associated with RBC and that the metabolism of RBC FAEE and plasma FAEE (bound to albumin or lipoproteins) are largely independent.


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C. A. BEST, M. LAPOSATA, V. G. PROIOS, and Z. M. SZCZEPIORKOWSKI
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A. BISAGA, M. LAPOSATA, S. XIE, and S. M. EVANS
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