Single session exercise stimulates formation of prebeta1-HDL in leg muscle

Dmitri Sviridov, Bronwyn Kingwell, Anh Hoang, Anthony Dart, and Paul Nestel

Baker Medical Research Institute, Melbourne, Vic 8008

Corresponding Author: Dmitri.Sviridov{at}Baker.edu.au

Physical activity can raise the level of circulating high density lipoprotein (HDL) cholesterol. Prebeta1-HDL is thought to be either the initial acceptor of cellular cholesterol or virtually the first particle in the pathway of the formation of HDL from apolipoprotein A-I and cellular lipids. We have therefore sought to identify prebeta1-HDL in arterial and venous circulations of exercising legs in healthy individuals and in subjects with stable Type 2 diabetes mellitus. Blood samples were taken simultaneously from the femoral artery and vein before and after 25 min cycling exercise. The major findings were first, that exercise significantly increased plasma concentration of prebeta1-HDL (20% increase, p<0.05) and second, that the prebeta1-HDL concentration was significantly higher in the venous compared to the arterial blood both before and after exercise in both diabetics and controls. In the combined population, formation of prebeta1-HDL at rest was 9.9 ± 5.2 mg/min and exercise enhanced prebeta1-HDL formation 6.6 fold in both groups.

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