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Papers In Press, published online ahead of print April 16, 2003
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Vascular Medicine and Metabolism, University Medical Center Utrecht, Utrecht, Utrecht 3584 CX
Corresponding Author: b.prinsen{at}azu.nl
Subjects with high plasma cholesterol levels exhibit a high production of VLDL apoB100, suggesting that cholesterol is a mediator for VLDL-production. The objective of the study was to examine whether endogenous cholesterol synthesis, reflected by lathosterol/cholesterol ratio (L/C ratio), affect the secretory rates of different VLDL subfractions. Ten healthy subjects were studied after overnight fasting. During a 10 h primed, constant infusion of 13C valine (15 µmol/kg/hr), enrichment was determined in apoB100 from ultracentrifugally isolated VLDL-1 and VLDL-2 by GCMS. The synthesis rates of VLDL-1 apoB100 and VLDL-2 apoB100, catabolism and transfer were estimated by compartmental analysis. Mean VLDL-1 apoB100 poolsize was 90 ± 15 mg and mean VLDL-2 apoB100 poolsize was 111 ± 14 mg. Absolute synthesis rate of VLDL-1 apoB100 was 649 ± 127 mg/day and 353 ± 59 mg/day for VLDL-2 apoB100. There was a strong association between the ASR of VLDL-2 apoB100 and L/C ratio (r2= 0.61, p<0.01). In contrast, no correlation was observed between L/C ratio and absolute synthesis rate of VLDL-1 apoB100 (r2=0.302, p=0.09). In conclusion, these data provide additional support for an independent regulation of VLDL-1 apoB100 and VLDL-2 apoB100 production. Endogenous cholesterol synthesis is correlated only with the VLDL-2 apoB100 production.
Revised on March 25, 2003
Accepted on April 10, 2003
Endogenous cholesterol synthesis is associated with VLDL-2 apoB-100 production in healthy humans
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