J. Lipid Res.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on May 1, 2003

Papers In Press, published online ahead of print February 16, 2003
J. Lipid Res., doi:10.1194/jlr.M300043-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
M300043-JLR200v1
44/5/986    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Couillard, C.
Right arrow Articles by Bergeron, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Couillard, C.
Right arrow Articles by Bergeron, J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Submitted on January 28, 2003
Revised on February 16, 2003
Accepted on February 5, 2003

Effect of apolipoprotein CIII gene polymorphisms on the lipoprotein-lipid profile of viscerally obese men

Charles Couillard, Marie-Claude Vohl, James C. Engert, Isabelle Lemieux, Alain Houde, Natalie Alméras, Denis Prud'homme, André Nadeau, Jean-Pierre ;Després, and Jean Bergeron

Lipid Research Center, CHUQ Research Center, CHUL Pavilion, Québec, Québec G1V4G2

Corresponding Author: Jean.Bergeron{at}crchul.ulaval.ca

Abdominal visceral adipose tissue (AT) accumulation is associated with an atherogenic metabolic profile which includes increased plasma TG, low HDL cholesterol levels and an insulin resistant-hyperinsulinemic state. Whereas the apolipoprotein (apo) CIII C3238G gene variant, often referred to as the SstI polymorphism, has been related to variations in plasma TG concentrations, another variation within the insulin-responsive element (IRE, C-482T) of the apoCIII gene has been associated with greater glucose and insulin responses to an oral glucose tolerance test (OGTT). However, these results were obtained in nonobese individuals. We therefore investigated the effects of three apoCIII gene polymorphisms, namely SstI, C-482T and T-455C, on fasting plasma lipoprotein-lipid levels and response to a 75-g OGTT in a sample of 122 viscerally obese men (abdominal visceral AT area >130 cm2). Among the three gene variants that were examined, the SstI variation was the only one found to have a hypertriglyceridemic effect. Indeed, S1/S2 heterozygotes (n=24) were characterized by increased fasting plasma TG concentrations compared to S1/S1 homozygotes (n=98) (mean ± SD: 3.03 ± 1.58 vs. 2.34 ± 0.95 mmol/L respectively, p<0.05). The higher TG concentrations in S1/S2 were associated with the presence of smaller, denser LDL particles compared to S1/S1 subjects (LDL peak particle diameter: 24.8 ± 0.5 nm vs. 25.1 ± 0.5 nm respectively, p<0.05). Furthermore, there was no association between the response to the OGTT and any of the apoCIII gene variants (SstI, T-455C or C-482T) examined. Results of the present study support the notion of a hypertriglyceridemic effect associated with the apoCIII SstI polymorphism which could modulate the magnitude of the dyslipidemic state in abdominally obese patients.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2003 by the American Society for Biochemistry and Molecular Biology.