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Papers In Press, published online ahead of print June 1, 2003
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Department of Medicine, University of Helsinki, Helsinki, HYKS 00029
Corresponding Author: mataskin{at}cc.helsinki.fi
In familial combined hyperlipidemia (FCHL), affected family members frequently have reduced levels of HDL-C, in addition to elevated levels of total cholesterol (TC) and/or triglycerides (TGs). In the present study, we focused on those determinants that are important regulators of HDL-C levels in FCHL, and measured postheparin plasma activities of hepatic lipase (HL) and lipoprotein lipase (LPL), and activities of cholesterol ester transfer protein (CETP) and phospholipid transfer protein (PLTP) in 228 subjects from 49 FCHL families. In affected family members (n=88), the levels of HDL-C, HDL2-C, HDL3-C and apolipoprotein A-I (apoA-I) were lower than in unaffected family members (n=88) or spouses (n=52). The main change was the reduction of HDL2-C by 25.4% in affected family members (P<0.001 vs. unaffected family members, P=0.003 vs. spouses). Affected family members had higher HL activity than unaffected family members (P=0.001) or spouses (P=0.013). PLTP activity was higher in affected than unaffected family members (P=0.025). In univariate correlation analysis, a strong negative correlation was observed between HL activity and HDL2-C (r=-0.339, P<0.001). Multivariate regression analysis demonstrated that gender, HL activity, TG and body mass index (BMI) have an independent contribution to HDL2 –C level. We suggest that in FCHL, TG-enrichment of HDL particles and enhanced HL activity lead to the reduction of HDL-C and HDL2-C.
Revised on April 23, 2003
Accepted on May 19, 2003
Determinants of low HDL levels in familial combined hyperlipidemia
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