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Papers In Press, published online ahead of print May 16, 2003
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Unité de Nutrition et Sécurité Alimentaire, INRA, Jouy-en-Josas 78352
Corresponding Author: sabah.aid{at}jouy.inra.fr
Because brain membranes contain large amounts of docosahexaenoic acid (DHA, 22:6n-3), and as (n-3) PUFA dietary deficiency can lead to impaired attention, learning and memory performance in rodents, we have examined the influence of a (n-3) PUFA deprived diet on the central cholinergic neurotransmission system. We have focused on several cholinergic neurochemical parameters in the frontal cortex and hippocampus of rats fed an (n-3) PUFA-deficient diet, compared to rats fed a control diet. The (n-3) PUFA deficiency resulted in changes in the membrane phospholipid compositions of both brain regions, with a dramatic loss (62-77 %) of DHA. However, the cholinergic pathway was only modified in the hippocampus and not in the frontal cortex. The basal acetylcholine release in the hippocampus of deficient rats was significantly (72 %) higher than in controls, whereas the KCl-induced release was lower (34 %). The (n-3) PUFA deprivation also caused a 10 % reduction in muscarinic receptor binding. In contrast, acetylcholinesterase activity and the vesicular acetylcholine transporter in both brain regions were unchanged. Thus, we evidenced that (n-3) PUFA deficient diet can affect cholinergic neurotransmission, probably via changes in the phospholipid PUFA composition.
Revised on May 2, 2003
Accepted on May 5, 2003
Effect of a diet-induced (n-3) polyunsaturated fatty acid depletion on cholinergic parameters in the rat hippocampus
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