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Papers In Press, published online ahead of print May 1, 2003
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INSERM U525, Faculté de Médecine Pitié-Salpétrière, Paris 75634
Corresponding Author: ninio{at}chups.jussieu.fr
Inflammation underlies both onset and perpetuation of atherosclerosis. Plasma lipoproteins transport the PAF-acetylhydrolase (PAF-AH) with potentially anti-inflammatory activities. Our aim was to determine whether PAF-AH activity was associated with inflammatory markers and with coronary artery disease (CAD). PAF-AH activity and a panel of inflammatory mediators were measured in plasma of 496 patients with CAD and in 477 controls; 276 patients presented with stable angina pectoris and 220 with acute coronary syndrome. Individuals within the highest quartile of PAF-AH activity had a 1.8-fold increase in CAD risk (95% CI 1.01 to 3.2, P=0.048) compared to those in the first quartile (adjusted for clinical and metabolic factors). When excluding individuals receiving statin and ACE-inhibitor medication, individuals within the highest quartile of PAF-AH activity revealed a 3.9-fold increase in CAD risk (95%CI 2.0 to 7.7, P<0.0001). In these subjects, the plasma PAF-AH activity raised gradually in stable angina and in acute coronary syndrome both in men (P<0.0001) and in women (P<0.001), as compared to controls. No correlation was found between PAF-AH levels and those of common markers of inflammation. This study and the previous ones raises an important issue whether PAF-AH is simply a marker of risk or it directly promotes atherosclerosis.
Revised on April 22, 2003
Accepted on April 22, 2003
Plasma PAF-acetylhydrolase in patients with coronary artery disease: results of a cross-sectional analysis
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