J. Lipid Res.
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A more recent version of this article appeared on September 1, 2003

Papers In Press, published online ahead of print May 1, 2003
J. Lipid Res., doi:10.1194/jlr.M300089-JLR200
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Submitted on February 24, 2003
Revised on April 17, 2003
Accepted on May 1, 2003

Phytosterols in low-and non-fat beverages as part of a controlled diet fail to lower plasma lipid levels

Peter JH Jones, Catherine A Vanstone, Mahmoud Raieni-Sarjaz, and Marie-Pierre St-Onge

School of Dietetics and Human Nutrition, McGill University, Montreal, Quebec H9X 3V9

Corresponding Author: jonesp{at}macdonald.mcgill.ca

Background: Dietary phytosterols have been shown to reduce plasma cholesterol concentrations when consumed in different food matrices, but their effectiveness in non-fat or low-fat beverages has not been established. Objective: The objective of this study was to examine whether phytosterols alter plasma lipid levels when incorporated into non-fat or low-fat beverages. Design: Fifteen moderately hypercholesterolemic men and women consumed 3 precisely controlled diets for periods of 21 d each in random order. Diets contained either a non-fat placebo beverage (NF), a non-fat beverage with added phytosterols (NFPS) or a low-fat beverage with added phytosterols (LFPS). Results: Total cholesterol concentrations were not different between groups at endpoint, decreasing (P < 0.05) equally by 8.5, 11.6, and 10.1% with NF, NFPS, and LFPS consumption, respectively. There was no effect of dietary treatment on LDL-cholesterol concentrations, which decreased over time (P < 0.05) by 5, 10.4, and 8.5% with NF, NFPS, and LFPS, respectively. HDL-cholesterol and triglyceride concentrations were unaffected by the diets. Conclusion: Provision of phytosterols, as part of non-fat and low-fat beverages did not exert any greater hypocholesterolemic effect than a non-fat placebo beverage. These results show that intake of phytosterols in a low-fat beverage format is not efficacious for lipid level modification.


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