J. Lipid Res.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on August 1, 2003

Papers In Press, published online ahead of print May 16, 2003
J. Lipid Res., doi:10.1194/jlr.M300097-JLR200
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
M300097-JLR200v1
44/8/1566    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by DeKroon, R. M.
Right arrow Articles by Strittmatter, W. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by DeKroon, R. M.
Right arrow Articles by Strittmatter, W. J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Submitted on February 28, 2003
Revised on May 7, 2003
Accepted on May 15, 2003

Apolipoprotein E genotype: specific inhibition of apoptosis

Robert M. DeKroon, Mirta Mihovilovic, Zoe V. Goodger, Jennifer B. Robinette, Patrick M. Sullivan, Ann M. Saunders, and Warren J. Strittmatter

Department of Medicine, Duke University Medical Center, Durham, NC 27710

Corresponding Author: warren{at}neuro.duke.edu

Endothelial cell apoptosis can be initiated by withdrawing growth factors or serum, and is inhibited by high-density lipoproteins (HDL). Our results show that the total lipoprotein population from apolipoprotein E 4/4 (APOE 4/4) sera is less anti-apoptotic than total lipoproteins from other APOE genotypes, as measured by caspase 3/7 activity. Moreover, APOE 4/4 very low-density lipoprotein (VLDL) antagonizes the anti-apoptotic activity of HDL, by a mechanism requiring binding of apoE4 on VLDL particles to an LDL-family receptor. This ability of APOE 4/4 VLDL to inhibit the anti-apoptotic effects of HDL presents a potential mechanism by which the expression of several diseases, including atherosclerosis, is enhanced by the APOE4 genotype.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Immunol.Home page
O. M. Kattan, F. B. Kasravi, E. L. Elford, M. T. Schell, and H. W. Harris
Apolipoprotein E-Mediated Immune Regulation in Sepsis
J. Immunol., July 15, 2008; 181(2): 1399 - 1408.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
M. Mihovilovic, J. B. Robinette, R. M. DeKroon, P. M. Sullivan, and W. J. Strittmatter
High-fat/high-cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL
J. Lipid Res., April 1, 2007; 48(4): 806 - 815.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
R. DeKroon, J. B. Robinette, A. B. Hjelmeland, E. Wiggins, M. Blackwell, M. Mihovilovic, M. Fujii, J. York, J. Hart, C. Kontos, et al.
APOE4-VLDL Inhibits the HDL-Activated Phosphatidylinositol 3-Kinase/Akt Pathway via the Phosphoinositol Phosphatase SHIP2
Circ. Res., October 13, 2006; 99(8): 829 - 836.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
X. Huang, P. C. Chen, and C. Poole
APOE-{epsilon}2 allele associated with higher prevalence of sporadic Parkinson disease
Neurology, June 22, 2004; 62(12): 2198 - 2202.
[Abstract] [Full Text] [PDF]

Home page
 Sci Aging Knowl EnvironHome page
J. Raber
Androgens, ApoE, and Alzheimer's Disease
Sci. Aging Knowl. Environ., March 17, 2004; 2004(11): re2 - re2.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2003 by the American Society for Biochemistry and Molecular Biology.