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Papers In Press, published online ahead of print July 16, 2003
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Department of Human Nutrition, University of Illinois at Chicago, Chicago, IL 60612
Corresponding Author: pbowen{at}uic.edu
A physiological pharmacokinetic model was developed to describe the disposition of lycopene, delivered as a tomato beverage formulation at 5 graded doses (10, 30, 60, 90 or 120 mg), for a Phase I study in healthy male subjects (5 per dose). Blood was collected before dose administration (0 hour) and at scheduled intervals until 672 hours. Serum concentrations of carotenoids and vitamins were measured by HPLC analysis. The model was comprised of 7 compartments: gastrointestinal tract, enterocytes, chylomicrons, plasma lipoproteins, fast-turnover liver, slow-turnover tissues and a delay compartment before the enterocytes. The predicted % absorption at the 10 mg dose (33.9 +/- 8.1 %) was significantly greater than at the higher doses, however, the amount of lycopene absorbed (mg) was not statistically different (mean: 4.69 +/- 0.55 mg) between doses, suggesting a possible saturation of absorptive mechanisms. The slow-turnover tissue compartment served as a slow depleting reservoir for lycopene and the liver represented the fast-turnover pool. Independent of dose, 80% of the subjects absorbed less than 6 mg of lycopene. This may have important implications for planning clinical trials with pharmacological doses of lycopene in cancer control and prevention, if absorption saturation occurs at levels that are already being consumed in the population.
Revised on July 1, 2003
Accepted on July 2, 2003
A physiological pharmacokinetic model describing the disposition of lycopene in healthy men
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