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A more recent version of this article appeared on October 1, 2003

Papers In Press, published online ahead of print July 16, 2003
J. Lipid Res., doi:10.1194/jlr.M300146-JLR200
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Submitted on April 8, 2003
Revised on June 2, 2003
Accepted on July 16, 2003

The effect of vitamin E on the structure of membrane lipid assemblies

A. Bradford, J. Atkinson, N. Fuller, and R. P. Rand

Biological Sciences, Brock University, St.Catharines, Ontario L2S 3A1

Corresponding Author: rrand{at}brocku.ca

The effects of vitamin E on the activity of membrane-dependent enzymes suggest that it acts indirectly by modifying some properties of the lipid host. The effects of <IMG SRC="/math/alpha.gif" ALIGN="BASELINE" ALT="alpha ">-tocopherol (<IMG SRC="/math/alpha.gif" ALIGN="BASELINE" ALT="alpha ">-T) and <IMG SRC="/math/alpha.gif" ALIGN="BASELINE" ALT="alpha ">-tocopherol hemisuccinate (<IMG SRC="/math/alpha.gif" ALIGN="BASELINE" ALT="alpha ">-THS) on phospholipid monolayer structure, curvature and bending elasticity were examined using X-ray diffraction and the osmotic stress method. These ligands were mixed with the hexagonal phase-forming lipid, dioleoylphosphatidylethanolamine (DOPE). Increasing levels up to 50 mole percent <IMG SRC="/math/alpha.gif" ALIGN="BASELINE" ALT="alpha ">-T in DOPE, in excess water, result in a systematic decrease in the lattice dimension. Analysis of the structural changes imposed by <IMG SRC="/math/alpha.gif" ALIGN="BASELINE" ALT="alpha ">-T shows that it contributes a spontaneous radius of curvature (Ro) of -13.7&#197;. This unusually negative value is comparable to diacyglycerols. <IMG SRC="/math/alpha.gif" ALIGN="BASELINE" ALT="alpha ">-T does not affect the bending elasticity of these monolayers. <IMG SRC="/math/alpha.gif" ALIGN="BASELINE" ALT="alpha ">-THS in its charged form decreases membrane curvature but in its undissociated neutral form has a qualitatively similar but reduced effect on monolayer curvature as does <IMG SRC="/math/alpha.gif" ALIGN="BASELINE" ALT="alpha ">-T. We discuss these results in terms of the local stresses such ligands would produce in the vicinity of a membrane protein, and how one might expect proteins to respond to such stress.


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