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J. Lipid Res.
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A more recent version of this article appeared on January 1, 2004

Papers In Press, published online ahead of print October 16, 2003
J. Lipid Res., doi:10.1194/jlr.M300148-JLR200
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Submitted on April 9, 2003
Revised on October 13, 2003
Accepted on October 13, 2003

Rate of gastric emptying influences dietary cholesterol absorption efficiency in selected inbred strains of mice

R. Jason Kirby, Philip N. Howles, and David Y. Hui

Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0529

Corresponding Author: huidy{at}email.uc.edu

This study compared the physiological process of cholesterol absorption in different strains of inbred mice with the goal of identifying novel mechanism(s) by which cholesterol absorption can be controlled. The rate and amount of cholesterol absorption were evaluated based on [14C]cholesterol appearance in plasma after feeding a meal containing [14C]cholesterol, and by the percentage of [14C]cholesterol absorbed over a 24 hr period. Results showed that the rate of [14C]cholesterol appearance in plasma was slower in 129P3/J mice than SJL/J mice. However, more dietary cholesterol was absorbed over a 24-hr period by 129P3/J mice than SJL/J mice. In both strains of mice, cholesterol delivered with medium-chain triglyceride was absorbed less efficiently than cholesterol delivered with olive oil. The strain- and vehicle-dependent differences in cholesterol absorption efficiency correlated negatively with stomach emptying rates. Furthermore, inhibition of gastric emptying with nitric oxide synthase inhibitor increased cholesterol absorption efficiency in SJL/J mice. These results document that stomach emptying rate contributes directly to the rate of dietary cholesterol absorption, which is inversely correlated to the total amount of cholesterol absorbed from a single meal. Additionally, genetic factor(s) that influence gastric emptying may be an important determinant in dictating cholesterol absorption efficiency.


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