J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
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A more recent version of this article appeared on October 1, 2003

Papers In Press, published online ahead of print July 16, 2003
J. Lipid Res., doi:10.1194/jlr.M300172-JLR200
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Submitted on April 24, 2003
Revised on July 7, 2003
Accepted on July 8, 2003

A fish oil diet produces different degrees of suppression of Apo B and triglyceride secretion in human Apo B transgenic mouse strains

Carol Ko, Shawn M. O’Rourke, and Li-Shin Huang

Medicine, Columbia University, New York, NY 10032

Corresponding Author: lh99{at}columbia.edu

Human apolipoprotein (apo) B transgenic (HuBTg) mouse strains were used to assess genetic effects on the response to fish oil, a source of n-3 fatty acids. A congenic HuBTg strain of the C57BL/6 (B6) background and six F1 HuBTg strains were fed a fish oil diet (FO) for 2 weeks. Different responses of plasma lipid levels to FO were observed among these strains. In particular, plasma apo B levels changed minimally in FO-fed male B6 HuBTg mice, but increased markedly (~40%) in FO-fed male FVBxB6 F1 HuBTg mice. These strain differences were determined mainly by hepatic apo B secretion rates and were likely regulated by post-transcriptional mechanisms. In addition, plasma triglyceride levels were reduced (14%) in FO-fed B6 mice but not in FVBxB6 mice. These strain differences were determined mainly by triglyceride secretion rates, but were not due to differences in hepatic lipogenesis. Hepatic mRNA levels of acyl-CoA oxidase, reflective of peroxisomal beta -oxidation rate, were increased in FO-fed B6 but not in FVBxB6 mice, which could account for the difference in triglyceride secretion rates. In summary, differential effects of FO on plasma apo B and triglyceride levels in B6 and FVBxB6 HuBTg mice were associated with strain differences in hepatic apo B and triglyceride secretion and in peroxisomal beta -oxidation.


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