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Papers In Press, published online ahead of print January 16, 2004
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Department of Nutrition and Genomics, Tufts University, Boston, MA 02111
Corresponding Author: jose.ordovas{at}tufts.edu
We have investigated the association of C1431T and Pro12Ala polymorphisms at the peroxisome proliferator-activated receptor g (PPARg) locus with plasma lipids and insulin resistance-related variables, according to diabetes status, in a large and representative Asian population from Singapore consisting of 2730 Chinese, 740 Malays and 568 Asian-Indians. Moreover, we estimated the diabetes risk and examined gene-nutrient interactions between these variants and the ratio of polyunsaturated fat (PUFA) to saturated fat (SFA) in determining body mass index (BMI) and fasting insulin. We have found differential effect of these gene variants. The Pro12Ala polymorphism was more associated with plasma lipids and fasting glucose concentrations, whereas, the C1431T polymorphism was related to the risk of diabetes. Carriers of the 12Ala allele had higher HDL-C than Pro12Pro homozygotes (P<0.05), and the effect of the 12Ala allele on fasting glucose was modified by the diabetes status (P<0.001). After controlling for confounders, carriers of the T allele had decreased risk of diabetes as compared with CC homozygotes (OR:0.73; 95%CI, 0.58-0.93; P=0.011); this effect was stronger in Asian Indians. For both polymorphisms, normal subjects carrying the less prevalent allele had higher BMI (P<0.05). The PUFA/SFA did not modify the effect of these polymorphisms on BMI or insulin.
Revised on January 5, 2004
Accepted on January 6, 2004
Differential effects of the C1431T and Pro12Ala PPAR
gene variants on plasma lipids and diabetes risk in an Asian population: the 1998 Singapore National Health Survey
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