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A more recent version of this article appeared on March 1, 2004

Papers In Press, published online ahead of print December 1, 2003
J. Lipid Res., doi:10.1194/jlr.M300374-JLR200
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Submitted on September 4, 2003
Revised on October 23, 2003
Accepted on November 25, 2003

Selective changes of docosahexaenoic acid-containing phospholipid molecular species in monkey testis during puberty

Don S. Lin, Martha Neuringer, and William E. Connor

Medicine/Clinical Nutrition, Dept. of Medicine, L 465, Oregon Health & Science University, Portland, OR 97239

Corresponding Author: connorw{at}ohsu.edu

Puberty has a profound effect upon the biochemical composition of the testis. We previously demonstrated that puberty was accompanied by great increases in the content of docosahexaenoic acid (DHA, 22:6 n-3) and dihomogamma-linoleic acid (20:3 n-6) and decreases in arachidonic acid (AA, 20:4 n-6) in the phospholipids of testis. In this report we analyzed the composition of the phospholipid molecular species of the ethanolamine and choline glycerophospholipids in the testis of pre-pubertal (2 yr. old) and young adult (7-8 yr. old) monkeys, There was an increase in the DHA species and a decrease in arachidonic species. Interestingly, with few exceptions, among the three molecular with DHA or AA at Sn-2 position, only16:0-22:6 and18:0-20:4 changed selectively in opposite directions for both ethanolamine and choline glycerophospholipids. In contast, there was on such selectivity seen in molecular species containing dihomogamma-linoleic acid or linoleic acid in sn-2 position. All three dihomogamma-linoleic acid species increased and all three lenoleic acid species decreased during puberty. In summary, at puberty the onset of spermatogenesis there are selective changes in the phospholipid molecular species, particularly those containing DHA and AA. These changes suggest a specific functional role of DHA-containing molecular species in the lipid bilayer membranes of sperm cells. A possible link between the composition of DHA-phospholipid molecular species and cellular function is discussed.


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