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Papers In Press, published online ahead of print February 1, 2004
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Institute of Human Nutrition, University of Southampton, Southampton, Hampshire SO16 7PX
Corresponding Author: g.c.burdge{at}soton.ac.uk
This study investigated the incorporation of cis-9, trans-11 conjugated linoleic acid (c9,t11 CLA) and trans-10, cis-12 CLA (t10,c12 CLA) into plasma and peripheral blood mononuclear cell (PBMC) lipids when consumed as supplements highly enriched in these isomers. Healthy men (n=49, aged 31±8 years) consumed 1, 2 and 4 capsules containing approximately 600mg of either c9,t11 CLA or t10,c12 CLA per capsule for sequential 8 week periods followed by 6 weeks washout before consuming the alternate isomer. Both isomers were incorporated in a dose-dependent manner into plasma phosphatidylcholine (PC) (c9,t11 CLA r= 0.779; t10,c12 CLA r=0.738; p<0.0001) and cholesteryl esters (CE) (c9,t11 CLA r=0.706; t10,c12 CLA r=0.788; p<0.0001). Only t10,c12 CLA was enriched in plasma non-esterified fatty acids. Both c9, t11 CLA and t10,c12 CLA were incorporated linearly into PBMC total lipids (r=0.285 and r=0.273, respectively; p<0.0005). The highest concentrations of c9,t11 CLA and t10,c12 CLA in PBMC lipids were 3- to 4- fold lower than in plasma PC and CE. These data suggest that the level of intake is a major determinant of plasma and PBMC CLA content, although PBMCs appear to incorporate both CLA isomers less readily.
Revised on January 12, 2004
Accepted on January 21, 2004
Incorporation of cis-9, trans-11 or trans-10, cis-12 conjugated linoleic acid into plasma and cellular lipids in healthy men
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